Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hong Q. Yan"'
Autor:
Lloyd D. Harvey, Yan Yin, Insiya Y. Attarwala, Gulnaz Begum, Julia Deng, Hong Q. Yan, C. Edward Dixon, Dandan Sun
Publikováno v:
ASN Neuro, Vol 7 (2015)
We investigated the effects of the administration of docosahexaenoic acid (DHA) post-traumatic brain injury (TBI) on reducing neuroinflammation. TBI was induced by cortical contusion injury in Sprague Dawley rats. Either DHA (16 mg/kg in dimethyl sul
Externí odkaz:
https://doaj.org/article/cd93820fbd92492687eb460537fca915
Autor:
Shaun W. Carlson, Hong Q. Yan, M S Young, Youming Li, Milos D. Ikonomovic, C E Dixon, Jeremy Henchir, Xiecheng Ma
Publikováno v:
Mol Neurobiol
Alpha synuclein (α-synuclein) is a neuronal protein found predominately in pre-synaptic terminals. While the pathological effects of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention ha
Autor:
Ruchira M. Jha, Stefania Mondello, Helen M. Bramlett, C. Edward Dixon, Deborah A. Shear, W. Dalton Dietrich, Kevin K.W. Wang, Zhihui Yang, Ronald L. Hayes, Samuel M. Poloyac, Philip E. Empey, Audrey D. Lafrenaye, Hong Q. Yan, Shaun W. Carlson, John T. Povlishock, Janice S. Gilsdorf, Patrick M. Kochanek
Publikováno v:
J Neurotrauma
Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774664fbb691a0c860d906bfd3a94e71
http://hdl.handle.net/11570/3190318
http://hdl.handle.net/11570/3190318
Autor:
Kevin K.W. Wang, W. Dalton Dietrich, Hong Q. Yan, John T. Povlishock, Patrick M. Kochanek, Philip E. Empey, Ying Deng-Bryant, C. Edward Dixon, Helen M. Bramlett, Ronald L. Hayes, Stefania Mondello, Frank C. Tortella, Deborah A. Shear
Publikováno v:
Journal of Neurotrauma. 33:553-566
Operation Brain Trauma Therapy (OBTT) is a consortium of investigators using multiple pre-clinical models of traumatic brain injury (TBI) to bring acute therapies to clinical trials. To screen therapies, we used three rat models (parasagittal fluid p
Autor:
Kirill Kiselyov, Yan Yin, C. Edward Dixon, T. Kevin Hitchens, Lesley M. Foley, Hong Q. Yan, Eric Li, George Sun, Dandan Sun, Liwia A. Andrzejczuk, Insiya Y. Attarwala
Publikováno v:
Molecular neurobiology. 55(3)
Traumatic brain injury (TBI) triggers endoplasmic reticulum (ER) stress and impairs autophagic clearance of damaged organelles and toxic macromolecules. In this study, we investigated the effects of the post-TBI administration of docosahexaenoic acid
Publikováno v:
The Journal of Neuroscience. 34:3743-3755
In this study, we investigated the development of endoplasmic reticulum (ER) stress after traumatic brain injury (TBI) and the efficacy of post-TBI administration of docosahexaenoic acid (DHA) in reducing ER stress. TBI was induced by cortical contus
Autor:
C. Edward Dixon, Valerian E. Kagan, David V. Ritzel, Robert H. Garman, Patrick M. Kochanek, Hong Q. Yan, Geoffrey S.F. Ling, David Shellington, Richard A. Bauman, Larry W. Jenkins, Samuel S. Shin, Edwin K. Jackson, Robert S. B. Clark, Faris A. Bandak, Hülya Bayır, Peter V. Swauger, Steven Parks
Publikováno v:
Journal of Neurotrauma. 30:920-937
Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic stress disorder, memory loss, and chronic traumatic encephalopathy. In this article we report on blast-i
Autor:
James W. Bales, Hong Q. Yan, James Lyons-Weiler, Samuel S. Shin, Amy K. Wagner, C. Edward Dixon, Anthony E. Kline
Publikováno v:
Journal of Neurotrauma. 30:259-270
Experimental investigations into the effects of traumatic brain injury (TBI) have demonstrated significant alterations in dopaminergic systems. Dopaminergic fibers originating within the substantia nigra and ventral tegmental area (VTA) are important
Autor:
Philip E. Empey, Hong Q. Yan, Zhihui Yang, Helen M. Bramlett, Kevin K.W. Wang, Samuel M. Poloyac, Janice S. Gilsdorf, Patrick M. Kochanek, Shaun W. Carlson, Stefania Mondello, C. Edward Dixon, W. Dalton Dietrich, Ruchira M. Jha, John T. Povlishock, Ronald L. Hayes, Audrey D. Lafrenaye, Deborah A. Shear
Publikováno v:
Journal of neurotrauma. 33(6)
Nicotinamide (vitamin B3) was the first drug selected for cross-model testing by the Operation Brain Trauma Therapy (OBTT) consortium based on a compelling record of positive results in pre-clinical models of traumatic brain injury (TBI). Adult male
Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy
Autor:
Ronald L. Hayes, Helen M. Bramlett, Frank C. Tortella, Deborah A. Shear, Philip E. Empey, Kevin K.W. Wang, Patrick M. Kochanek, Travis C. Jackson, Steven P. Richieri, Olena Glushakova, Megan Browning, Ying Deng-Bryant, C. Edward Dixon, Samuel M. Poloyac, John T. Povlishock, Andrea Mountney, Michael Catania, Hong Q. Yan, Stefania Mondello, W. Dalton Dietrich
Operation Brain Trauma Therapy (OBTT) is a fully operational, rigorous, and productive multicenter, pre-clinical drug and circulating biomarker screening consortium for the field of traumatic brain injury (TBI). In this article, we synthesize the fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3bb4e92e4a237e383b24fe4c0dbcf1
https://zenodo.org/record/895691
https://zenodo.org/record/895691