Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hong Mei Gu"'
Autor:
Hafsa Riaz, Bixia Zheng, Yucan Zheng, Zhifeng Liu, Hong-mei Gu, Muhammad Imran, Tahir Yaqoob, Munir Ahmad Bhinder, Da-wei Zhang, Muhammad Yasir Zahoor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Progressive familial intrahepatic cholestasis (PFIC) is a rare childhood manifested disease associated with impaired bile secretion with severe pruritus yellow stool, and sometimes hepatosplenomegaly. PFIC is caused by mutations in ATP8B1, A
Externí odkaz:
https://doaj.org/article/9c11e20f68744c7093b1934308737e22
Autor:
Bingxiang Wang, Huili Li, Govind Gill, Xiangyan Zhang, Geru Tao, Boyan Liu, Lei Zhai, Wei Chen, Hao Wang, Hong-mei Gu, Shucun Qin, Da-wei Zhang
Publikováno v:
Research, Vol 7 (2024)
Liver fibrosis is a severe global health problem. However, no effective antifibrotic drugs have been approved. Surf4 is primarily located in the endoplasmic reticulum (ER) and mediates the transport of secreted proteins from the ER to the Golgi appar
Externí odkaz:
https://doaj.org/article/5712bde382814d98832307c2602e926a
Autor:
Xiaole Chang, Yongfang Zhao, Shucun Qin, Hao Wang, Bingxiang Wang, Lei Zhai, Boyan Liu, Hong-mei Gu, Da-wei Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/13ef685a00ea48699ddd82a93117dcd6
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/95e96430948f4858adadf4f8d88e0677
Autor:
Maggie Wang, Adekunle Alabi, Hong-mei Gu, Govind Gill, Ziyang Zhang, Suha Jarad, Xiao-dan Xia, Yishi Shen, Gui-qing Wang, Da-wei Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the d
Externí odkaz:
https://doaj.org/article/17ee49369f4c40b6ac1d36ce257c95a4
Autor:
Adekunle Alabi, Xiao-Dan Xia, Hong-Mei Gu, Faqi Wang, Shi-Jun Deng, Nana Yang, Ayinuer Adijiang, Donna N. Douglas, Norman M. Kneteman, Yazhuo Xue, Li Chen, Shucun Qin, Guiqing Wang, Da-Wei Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of M
Externí odkaz:
https://doaj.org/article/d72c4682bad4414eafe52c4f12f492db
Autor:
Xiaole Chang, Yongfang Zhao, Shucun Qin, Hao Wang, Bingxiang Wang, Lei Zhai, Boyan Liu, Hong-mei Gu, Da-wei Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
The adrenal gland produces steroid hormones to play essential roles in regulating various physiological processes. Our previous studies showed that knockout of hepatic Surf4 (Surf4LKO) markedly reduced fasting plasma total cholesterol levels in adult
Externí odkaz:
https://doaj.org/article/84b52febdf334436bc9b08dc45d47669
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL cholesterol levels, lipoprotein(a) and triglyceride-rich lipoproteins, i
Externí odkaz:
https://doaj.org/article/9e06a02d33a94211b5c2257617677107
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 516-527 (2019)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth fac
Externí odkaz:
https://doaj.org/article/20e22f29dc094509a2ae980a6bfa0d83
Autor:
Geru Tao, Hao Wang, Yishi Shen, Lei Zhai, Boyan Liu, Bingxiang Wang, Wei Chen, Sijie Xing, Yuan Chen, Hong-Mei Gu, Shucun Qin, Da-Wei Zhang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:562-580
Background: Postprandial dyslipidemia is a causative risk factor for cardiovascular disease. The majority of absorbed dietary lipids are packaged into chylomicron and then delivered to circulation. Previous studies showed that Surf4 (surfeit locus pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1509a33a0481c8f3bf2a566762b67d
https://doi.org/10.1161/atvbaha.123.318980
https://doi.org/10.1161/atvbaha.123.318980