Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hong Jun Rhee"'
Autor:
Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2212-2228.e7 (2019)
Summary: iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized
Externí odkaz:
https://doaj.org/article/be79eb1df6054ca6a5dd84a11de59ece
Autor:
Simon A Ramsbottom, Vipul Sharma, Hong Jun Rhee, Lorraine Eley, Helen M Phillips, Hannah F Rigby, Charlotte Dean, Bill Chaudhry, Deborah J Henderson
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004871 (2014)
Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well as in o
Externí odkaz:
https://doaj.org/article/15d5009c01be42c08a567d264526619a
Autor:
Anes Ju, Bekir Altas, Hong Jun Rhee, Manuela Schwark, Imam Hassouna, Albrecht Sigler, Hiroshi Kawabe, Kamal Chowdhury, Hannelore Ehrenreich, Nils Brose, JeongSeop Rhee
Heterozygous mutation ofAmbra1, known as a positive autophagy regulator, produces autismlike behavior in mice and autistic phenotypes in humans in a female-specific manner. However, the substantial roles of theAmbra1mutation in neurons are still unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a39f8569cc28ea9588a712963d6037
https://doi.org/10.1101/2022.12.19.521004
https://doi.org/10.1101/2022.12.19.521004
Autor:
Rachel Straussberg, Marta Rosário, Guntram Borck, Victor Tarabykin, Olaf Jahn, Stephen Horan, A Ioana Weber, Rüstem Yilmaz, Ekrem Dere, Alina Smorodchenko, Hong Jun Rhee, Jeong-Seop Rhee, Susanne Mueller, Katrin I. Willig, Philipp Boehm-Sturm, Manuela Schwark, Mateusz C. Ambrozkiewicz, Sami Zaqout, Ekaterina Borisova, Theres Schaub, Bekir Altas, Silvia Ripamonti, Hiroshi Kawabe, Lars Piepkorn
Publikováno v:
Molecular Psychiatry. 26:1980-1995
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, encoding for a ubiquitin l
Autor:
Hong Jun Rhee, ChoongKu Lee, Anja Guenther, Carolina Thomas, Erinn S. Gideons, Ali H Shaib, Oliver Brüstle, Kristina Rehbach, Tamara Krutenko, Michael Peitz, Matthias Hebisch, Peter Seif, Jeong-Seop Rhee, Nils Brose
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2212-2228.e7 (2019)
Cell Reports
Cell Reports
Summary: iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized
Autor:
Chungku Lee, Johannes Brockhaus, Wenjia Guo, Markus Missler, Daniele Repetto, Hong Jun Rhee, Jeong-Seop Rhee, Manfred W. Kilimann, Lisa M. Northoff, Carsten Reissner
Publikováno v:
Frontiers in Synaptic Neuroscience
Frontiers in synaptic neuroscience
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
Frontiers in synaptic neuroscience
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
Spines are small protrusions from dendrites where most excitatory synapses reside. Changes in number, shape, and size of dendritic spines often reflect changes of neural activity in entire circuits or at individual synapses, making spines key structu
Autor:
Nils Brose, Foteini Paraskevopoulou, Heinrich Betz, Devaraj Subramanian, Theofilos Papadopoulos, Hong Jun Rhee, Carsten Schultz, Jeong-Seop Rhee, Rainer Mueller
Publikováno v:
The Journal of Biological Chemistry
The formation of neuronal synapses and the dynamic regulation of their efficacy depend on the proper assembly of the postsynaptic neurotransmitter receptor apparatus. Receptor recruitment to inhibitory GABAergic postsynapses requires the scaffold pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a26a4dcd85b18275ac3dc0878948c21
https://europepmc.org/articles/PMC5270463/
https://europepmc.org/articles/PMC5270463/
Autor:
ChoongKu Lee, Austin L. Wang, Ying Lai, Ucheor B. Choi, Minglei Zhao, Bekir Altas, Nils Brose, Hong Jun Rhee, Jeong-Seop Rhee, Axel T. Brunger, Jeremy Leitz, Richard A. Pfuetzner
Publikováno v:
Neuron. 95:591-607.e10
Summary Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary SNARE complex. Here we report a new function of Munc13, independent of Munc18: it promotes the proper syntaxin/synaptobrevin subconfiguration during a
Autor:
Hong-Jun Rhee, Jae-Ho Park, Edward H. Schuchman, Brynn Levy, Seung-Beom Hong, Chi-Ming Li, Ook Joon Yoo, Xingxuan He
Publikováno v:
Genomics. 62:232-241
Computer-assisted database analysis of sequences homologous to human acid ceramidase (ASAH) revealed a 1233-bp cDNA (previously designated cPj-LTR) whose 266-amino-acid open reading frame had approximately 36% identity with the ASAH polypeptide. Base
Publikováno v:
FEBS letters. 586(13)
The cardiovascular system consists of many cell types with distinct embryonic origins. Cells from an Islet1 (Isl1)-expressing progenitor population make a substantial contribution to the developing heart. We reasoned that cells derived from Isl1-expr