Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Hong Jen Lee"'
Autor:
Hong-Jen Lee, Chien-Feng Li, Diane Ruan, Jiabei He, Emily D. Montal, Sonja Lorenz, Geoffrey D. Girnun, Chia-Hsin Chan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of
Externí odkaz:
https://doaj.org/article/c1e48419d9bc4725802932966b49bd52
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and a
Externí odkaz:
https://doaj.org/article/c9d61ab415f44592a6666405a41b3488
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Edward T.H. Yeh, Yan Wang, Hui-Lung Sun, Chia-Jui Yen, Jennifer L. Hsu, Wen-Hsuan Yu, Weiya Xia, Heng-Huan Lee, Yi Du, Hong-Jen Lee, Hirohito Yamaguchi, Chun-Te Chen
Several antiangiogenic drugs targeting VEGF/VEGF receptor (VEGFR) that were approved by the Food and Drug Administration for many cancer types, including colorectal and lung cancer, can effectively reduce tumor growth. However, targeting the VEGF sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68c6b6cfc056a298ee311664f806ba7
https://doi.org/10.1158/1535-7163.c.6535329
https://doi.org/10.1158/1535-7163.c.6535329
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Edward T.H. Yeh, Yan Wang, Hui-Lung Sun, Chia-Jui Yen, Jennifer L. Hsu, Wen-Hsuan Yu, Weiya Xia, Heng-Huan Lee, Yi Du, Hong-Jen Lee, Hirohito Yamaguchi, Chun-Te Chen
Supplementary Figures 1-4 from Dual Targeting of Tumor Angiogenesis and Chemotherapy by Endostatin–Cytosine Deaminase–Uracil Phosphoribosyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521110bb67c27c15c1827288f0fb525c
https://doi.org/10.1158/1535-7163.22496592.v1
https://doi.org/10.1158/1535-7163.22496592.v1
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Edward T.H. Yeh, Yan Wang, Hui-Lung Sun, Chia-Jui Yen, Jennifer L. Hsu, Wen-Hsuan Yu, Weiya Xia, Heng-Huan Lee, Yi Du, Hong-Jen Lee, Hirohito Yamaguchi, Chun-Te Chen
Supplementary Methods from Dual Targeting of Tumor Angiogenesis and Chemotherapy by Endostatin–Cytosine Deaminase–Uracil Phosphoribosyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b74c342730440d62080b5119a777b3
https://doi.org/10.1158/1535-7163.22496589.v1
https://doi.org/10.1158/1535-7163.22496589.v1
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df703970576048fa84091840fb6750ac
https://doi.org/10.1096/fasebj.2021.35.s1.01731
https://doi.org/10.1096/fasebj.2021.35.s1.01731
Publikováno v:
2020 China Semiconductor Technology International Conference (CSTIC).
Hotspots often lead to unexpected critical dimension (CD) behavior, degradation of process window and ultimately impact wafer yield. The most important aspects of the patterning process in device manufacturing are to calibrate the OPC model, correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b4dc07c52657fd29a4f3982dadc89c
https://doi.org/10.1109/cstic49141.2020.9282384
https://doi.org/10.1109/cstic49141.2020.9282384
Publikováno v:
Oncogene
Castration-resistant prostate cancer (CRPC) remains a major clinical challenge due to the lack of effective targeted therapy for its treatment. The mechanism underlying how CRPC gains resistance towards hormone depletion and other forms of chemothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f464ae3c04958a46a02bc8b2a61047
https://doi.org/10.1038/onc.2017.64
https://doi.org/10.1038/onc.2017.64
Autor:
Diane Ruan, Chia Hsin Chan, Jiabei He, Hong-Jen Lee, Geoffrey D. Girnun, Sonja Lorenz, Chien Feng Li, Emily D. Montal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Enormous efforts have been made to target metabolic dependencies of cancer cells for developing new therapies. However, the therapeutic efficacy of glycolysis inhibitors is limited due to their inability to elicit cell death. Hexokinase 2 (HK2), via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901e65d8d33d65cd137c2711bcff636a
https://doi.org/10.1038/s41467-019-10374-y
https://doi.org/10.1038/s41467-019-10374-y
Autor:
Hong-Jen Lee, Patricia A. Thompson, Michael A. Frohman, Scott Powers, Chia Hsin Chan, Diane Ruan, Chien Feng Li
Publikováno v:
Molecular Cell. 63:1021-1033
Twist has been shown to cause treatment failure, cancer progression and cancer-related death. However, strategies that directly target Twist are not yet conceivable. Here we revealed K63-linked ubiquitination is a crucial regulatory mechanism for Twi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ccce97ad3e28824e7440153f41c63
https://doi.org/10.1016/j.molcel.2016.08.009
https://doi.org/10.1016/j.molcel.2016.08.009