Massively parallel characterization of insulator activity across the genome.

Autor: Hong CKY; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA., Wu Y; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA., Erickson AA; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA., Li J; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA., Federico AJ; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA., Cohen BA; The Edison Family Center for Genome Sciences and Systems Biology, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA. cohen@wustl.edu.; Department of Genetics, School of Medicine, Washington University in St. Louis, Saint Louis, MO, 63110, USA. cohen@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8350. Date of Electronic Publication: 2024 Sep 27.

A single-cell massively parallel reporter assay detects cell-type-specific gene regulation.

Autor: Zhao S; Edison Family Center for Systems Biology and Genome Sciences, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Ginkgo Bioworks, Boston, MA, USA., Hong CKY; Edison Family Center for Systems Biology and Genome Sciences, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Myers CA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Granas DM; Edison Family Center for Systems Biology and Genome Sciences, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., White MA; Edison Family Center for Systems Biology and Genome Sciences, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Corbo JC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Cohen BA; Edison Family Center for Systems Biology and Genome Sciences, Washington University School of Medicine, St. Louis, MO, USA. cohen@wustl.edu.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. cohen@wustl.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Feb; Vol. 55 (2), pp. 346-354. Date of Electronic Publication: 2023 Jan 12.

Single cell biology-a Keystone Symposia report.

Autor: Cable J; PhD Science Writer, New York, New York., Elowitz MB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California., Domingos AI; Department of Physiology, Anatomy & Genetics, Oxford University, Oxford, United Kingdom.; The Howard Hughes Medical Institute, New York, New York., Habib N; Cell Circuits Program, Broad Institute, Cambridge, Massachusetts.; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Itzkovitz S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Hamidzada H; Toronto General Hospital Research Institute, University Health Network; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research and Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Balzer MS; Renal, Electrolyte, and Hypertension Division, Department of Medicine and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Yanai I; Institute for Computational Medicine, NYU Langone Health, New York, New York., Liberali P; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Whited J; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts., Streets A; Department of Bioengineering and Center for Computational Biology, University of California, Berkeley, Berkeley, California.; Chan Zuckerberg Biohub, San Francisco, California., Cai L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California., Stergachis AB; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington; and Brotman Baty Institute for Precision Medicine, Seattle, Washington., Hong CKY; Edison Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, Missouri.; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri., Keren L; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Pathology, School of Medicine, Stanford University, Stanford, California., Guilliams M; Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, and Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Alon U; Faculty of Sciences, Department of Human Biology, University of Haifa, Haifa, Israel., Shalek AK; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts., Hamel R; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom., Pfau SJ; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts., Raj A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Quake SR; Chan Zuckerberg Biohub, San Francisco, California.; Department of Bioengineering, Stanford University, Stanford, California.; Department of Applied Physics, Stanford University, Stanford, California., Zhang NR; Graduate Group in Genomics and Computational Biology and Department of Statistics, University of Pennsylvania, Philadelphia, Pennsylvania., Fan J; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland., Trapnell C; Department of Genome Sciences, University of Washington School of Medicine; Brotman Baty Institute for Precision Medicine; and Allen Discovery Center for Cell Lineage Tracing, Seattle, Washington., Wang B; Department of Bioengineering, Stanford University, Stanford, California.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California., Greenwald NF; Department of Pathology, School of Medicine, Stanford University, Stanford, California., Vento-Tormo R; Wellcome Sanger Institute, Cambridgeshire, United Kingdom., Santos SDM; The Francis Crick Institute, London, United Kingdom., Spencer SL; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado., Garcia HG; Department of Physics; Biophysics Graduate Group; Department of Molecular and Cell Biology; and Institute for Quantitative Biosciences-QB3, University of California at Berkeley, Berkeley, California., Arekatla G; ETH Zurich, Zurich, Switzerland., Gaiti F; New York Genome Center and Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Arbel-Goren R; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel., Rulands S; Max Planck Institute for the Physics of Complex Systems, and Center for Systems Biology Dresden, Dresden, Germany., Junker JP; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Klein AM; Department of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., Morris SA; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri.; Department of Developmental Biology and Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, Missouri., Murray JI; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Galloway KE; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts., Ratz M; Department of Cell and Molecular Biology, Karolinska Institute, Solna, Sweden., Romeike M; Max Perutz Laboratories Vienna, University of Vienna, Vienna, Austria.

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Dec; Vol. 1506 (1), pp. 74-97. Date of Electronic Publication: 2021 Oct 03.