Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Hong C. Shen"'
Publikováno v:
Cells, Vol 11, Iss 23, p 3868 (2022)
As one of the leading causes of death from disease, cancer continues to pose a serious threat to human health globally. Despite the development of novel therapeutic regimens and drugs, the long-term survival of cancer patients is still very low, espe
Externí odkaz:
https://doaj.org/article/e99f4ed845df406d89450ad029fcfb69
Autor:
Weixing Zhang, Lei Guo, Haixia Liu, Guolong Wu, Houguang Shi, Mingwei Zhou, Zhisen Zhang, Buyu Kou, Taishan Hu, Zheng Zhou, Zhiheng Xu, Xue Zhou, Yuan Zhou, Xiaojun Tian, Guang Yang, John A. T. Young, Hongxia Qiu, Giorgio Ottaviani, Jianxun Xie, Alexander V. Mayweg, Hong C. Shen, Wei Zhu
Publikováno v:
Journal of Medicinal Chemistry. 66:4253-4270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055bed34cd0263d1a6af77825ad89e12
https://doi.org/10.1021/acs.jmedchem.3c00173
https://doi.org/10.1021/acs.jmedchem.3c00173
Autor:
Dongdong Chen, Xuefei Tan, Wenming Chen, Yongfu Liu, Chao Li, Jun Wu, Jiamin Zheng, Hong C. Shen, Meifang Zhang, Waikwong Wu, Lin Wang, Jing Xiong, Jieyu Dai, Kai Sun, Jitao David Zhang, Kunlun Xiang, Baocun Li, XiaoJu Ni, Qihui Zhu, Lu Gao, Li Wang, Song Feng
Publikováno v:
Journal of medicinal chemistry. 65(16)
Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of deaths per year. Currently, there is no therapeutic that can completely cure already infected HBV patients due to the inability of humans to eliminate covalentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fc68f85e6d088540ce2a2a47c4972e
https://pubmed.ncbi.nlm.nih.gov/35973101
https://pubmed.ncbi.nlm.nih.gov/35973101
Autor:
Muhammed Yousufuddin, Hong C. Shen, László Kürti, Yimin Hu, Juha H. Siitonen, Mahesh P. Paudyal, Mingliang Wang, John R. Falck
Publikováno v:
Organic & Biomolecular Chemistry. 19:557-560
A mild Rh-catalyzed method for synthesis of cyclic unprotected N-Me and N-H 2,3-aminoethers using an olefin aziridination-aziridine ring-opening domino reaction has been developed. The method is readily applicable to the stereocontrolled synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9dcd7e75d14918481db0085f32b111
https://doi.org/10.1039/d0ob02122a
https://doi.org/10.1039/d0ob02122a
Autor:
Maarten Vercruysse, Yimin Hu, Yunhua Xu, Hua Lv, Waikwong Wu, Fabian Dey, Tianyi Jiang, Xuefei Tan, Wen Wang, Ying Ji, Zhiheng Xu, Zhang Zhiwei, Yi Mao, Kenneth Bradley, Guanglei Zhai, Liu Yongqiang, Xiangyu Yao, Qingcheng Ren, Hong C. Shen, S. Frank Yan, Xiao Ding, Weixing Zhang, Xiaomin Yu, Shi Houguang, Zhu Wei, Chengang Zhou, Mingwei Zhou, Zheng Zhou
Publikováno v:
Journal of Medicinal Chemistry. 63:9623-9649
The rise of multidrug resistant (MDR) Gram-negative (GN) pathogens and the decline of available antibiotics that can effectively treat these severe infections are a major threat to modern medicine. Developing novel antibiotics against MDR GN pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7925b6d7c4055b2de9cff35400afc18
https://doi.org/10.1021/acs.jmedchem.0c00768
https://doi.org/10.1021/acs.jmedchem.0c00768
Publikováno v:
Chemistry Letters. 49:709-712
An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-su...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b1df7eaa8e01804826334740a485c98
https://doi.org/10.1246/cl.200142
https://doi.org/10.1246/cl.200142
Publikováno v:
The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270
Induction of cytochrome P450 enzymes, especially CYP3A4, could be a significant clinical issue leading to therapeutic efficacy reduction or even loss of a co-medication or the CYP3A4 inducer itself, because CYP3A4 alone is involved in the metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ad593673c413e112e7f3e87f5fd142e
https://doi.org/10.1039/9781788016414-00198
https://doi.org/10.1039/9781788016414-00198
Autor:
Hong C. Shen, Zhu Wei, Zongxing Qiu, Hongxia Qiu, Sheng Zhong, Zheng Zhou, Weixing Zhang, Xue Zhou, Guozhi Tang, Fabian Dey, Guang Yang, Xianfeng Lin, Jianxun Xie, Shi Houguang
Publikováno v:
Journal of Medicinal Chemistry. 62:10352-10361
Described herein is a new approach to mitigate CYP3A4 induction. In this unconventional approach, a fine-tuning of the dihedral angle between the C4 phenyl and the dihydropyrimidine core of the heteroaryldihydropyrimidine (HAP) class of capsid inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b153ad80711313c03dde97212d3e426
https://doi.org/10.1021/acs.jmedchem.9b01421
https://doi.org/10.1021/acs.jmedchem.9b01421
Autor:
Hongying Yun, Lu Gao, Lisha Wang, Baoxia Wang, Yongfu Liu, Mingwei Zhou, Kunlun Xiang, Zhang Bo, Li Chen, Xin Yu, Tao Guo, Chungen Liang, Song Feng, Jim Zhen Wu, Gang Zou, Zheng Xiufang, Hong C. Shen
Publikováno v:
Journal of Medicinal Chemistry. 62:6003-6014
Ziresovir (RO-0529, AK0529) is reported here for the first time as a promising respiratory syncytial virus (RSV) fusion (F) protein inhibitor that currently is in phase 2 clinical trials. This article describes the process of RO-0529 as a potent, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaa43b9bc9f40799676e30d45f3892a
https://doi.org/10.1021/acs.jmedchem.9b00654
https://doi.org/10.1021/acs.jmedchem.9b00654
Autor:
Hui Zhang, Xiao Ding, Liping Song, Jun Wu, Jie Chen, Xuefei Tan, Weiguo Cao, Hongmei Deng, Weimin He, Hong C. Shen
Publikováno v:
Journal of Fluorine Chemistry. 220:54-60
In the presence of Na2CO3, a variety of fluoroalkylated quinolones were efficiently synthesized from isatins and fluoroalk-2-ynoates in good to excellent yields at room temperature. The reaction can proceed via two different ways with Michael adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e82cb5c1f2b594972e7f72039c1bfa
https://doi.org/10.1016/j.jfluchem.2019.02.002
https://doi.org/10.1016/j.jfluchem.2019.02.002