Zobrazeno 1 - 10
of 474
pro vyhledávání: '"Hong‐Zhuan Chen"'
Publikováno v:
ACS Central Science, Vol 9, Iss 10, Pp 1864-1893 (2023)
Externí odkaz:
https://doaj.org/article/cae3c28587344e1ea2e003317d484aab
Autor:
Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen, Yu Qiu
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-18 (2023)
Abstract Background Ribosomal protein S6 kinase 1 (S6K1) is a serine–threonine kinase that has two main isoforms: p70S6K (70-kDa isoform) and p85S6K (85-kDa isoform). p70S6K, with its upstream mammalian target of rapamycin (mTOR), has been shown to
Externí odkaz:
https://doaj.org/article/7a4fe3561f9847d4b6ecb9f8834498b3
Publikováno v:
Journal of Electronic Science and Technology, Vol 21, Iss 3, Pp 100216- (2023)
This paper proposes an improved exponential curvature-compensated bandgap reference circuit to exploit the exponential relationship between the current gain β of the bipolar junction transistor (BJT) and the temperature as well as reduce the influen
Externí odkaz:
https://doaj.org/article/4de80bea58484c24a50308bbe3689188
Autor:
Xiang-Yu Liu, Mao-Hua Zhu, Xiao-Yu Wang, Xiao Dong, Hai-Jun Liu, Rui-Yang Li, Shi-Chong Jia, Qin Lu, Mei Zhao, Peng Sun, Hong-Zhuan Chen, Chao Fang
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Harnessing the immune system to fight cancer has led to prominent clinical successes. Strategies to stimulate innate immune effectors are attracting considerable interest in cancer therapy. Here, through conjugating multivalent Fc
Externí odkaz:
https://doaj.org/article/964439c5324b4c4294f327a7b9c4217b
Autor:
Jiashen Zhou, Lin Zhang, Liping Zeng, Lu Yu, Yuanyuan Duan, Siqi Shen, Jingyan Hu, Pan Zhang, Wenyan Song, Xiaoxue Ruan, Jing Jiang, Yinan Zhang, Lu Zhou, Jia Jia, Xudong Hang, Changlin Tian, Houwen Lin, Hong-Zhuan Chen, John E. Cronan, Hongkai Bi, Liang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cl
Externí odkaz:
https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf9
Autor:
Jinmei Jin, Yaping Wu, Zeng Zhao, Ye Wu, Yu-dong Zhou, Sanhong Liu, Qingyan Sun, Guizhu Yang, Jiayi Lin, Dale G. Nagle, Jiangjiang Qin, Zhiyuan Zhang, Hong-zhuan Chen, Weidong Zhang, Shuyang Sun, Xin Luan
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
The aberrant activation of STAT3 is associated with the etiology and progression in a variety of malignant epithelial-derived tumors, including head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC). Due to the lack of an enzymatic
Externí odkaz:
https://doaj.org/article/655ea3dd69dc4952b87fdc61cbdca2ff
Autor:
Shan-Shan Wang, Zi-Kai Liu, Jing-Jing Liu, Qing Cheng, Yan-Xia Wang, Yan Liu, Wen-Wen Ni, Hong-Zhuan Chen, Mingke Song
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background Discovery of early-stage biomarkers is a long-sought goal of Alzheimer’s disease (AD) diagnosis. Age is the greatest risk factor for most AD and accumulating evidence suggests that age-dependent elevation of asparaginyl endopept
Externí odkaz:
https://doaj.org/article/e3426329a5794106b0addde25315d1e3
Autor:
Hai-Yi Feng, Yihang Yuan, Yunpeng Zhang, Hai-Jun Liu, Xiao Dong, Si-Cong Yang, Xue-Liang Liu, Xing Lai, Mao-Hua Zhu, Jue Wang, Qin Lu, Quanjun Lin, Hong-Zhuan Chen, Jonathan F. Lovell, Peng Sun, Chao Fang
Publikováno v:
Nano-Micro Letters, Vol 13, Iss 1, Pp 1-17 (2021)
Highlights Small-sized trastuzumab-targeted micelles (T-MP) were engineered using a surfactant-stripping approach that yielded concentrated phthalocyanines with strong near infrared absorption. T-MP accumulated more in the lymph node (LN) metastases
Externí odkaz:
https://doaj.org/article/8de476ea904b418f997d95523e720074
Autor:
Wen-Jie Gu, Xiao-Xia Liu, Yi-Wen Shen, Yi-Ting Gong, Yi-Li Chen, Jiayi Lin, Dong Lu, Li-Jun Zhang, Hong-Zhuan Chen, Yi Jin, Zha-Jun Zhan, Wei-Dong Zhang, Jin-Mei Jin, Xin Luan
Publikováno v:
Theranostics; 2024, Vol. 14 Issue 18, p7023-7041, 19p
Autor:
Ju Wang, Hui-Jie Hu, Zi-Kai Liu, Jing-Jing Liu, Shan-Shan Wang, Qing Cheng, Hong-Zhuan Chen, Mingke Song
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-10 (2021)
Abstract Background Currently, there is no cure for Alzheimer’s disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent studies have shown that the pathogenesis of AD is closely regulated by an endo/lysosomal as
Externí odkaz:
https://doaj.org/article/84046f18c00d41b7a497e61639049ec7