Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Hong‐Li Guo"'
Autor:
Wei‐Jun Wang, Yue Li, Ya‐Hui Hu, Jie Wang, Yuan‐Yuan Zhang, Lin Fan, Hao‐Ran Dai, Hong‐Li Guo, Xuan‐Sheng Ding, Feng Chen
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1554-1569 (2024)
Abstract Significant pharmacokinetic (PK) differences exist between different forms of valproic acid (VPA), such as syrup and sustained‐release (SR) tablets. This study aimed to develop a population pharmacokinetic (PopPK) model for VPA in children
Externí odkaz:
https://doaj.org/article/68660539cbd647d18390b699ad6c73ab
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Pharmacogenetics/pharmacogenomics (PGx) focuses on the genetic variation that causes the heterogeneity of pharmacokinetics and drug response among individuals and has the potential to predict individual efficacy and/or side effect
Externí odkaz:
https://doaj.org/article/ae89aab4b482440e9f6a020ba6317568
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Non-stimulant atomoxetine is recognized in various current clinical guidelines as an important alternative to stimulants for the pharmacological treatment of attention deficit/hyperactivity disorder (ADHD) in children. While its efficacy and tolerabi
Externí odkaz:
https://doaj.org/article/82410c2ae1024b1f991f5da8572019e1
Autor:
Yue Li, Hong-Li Guo, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Lin Fan, Ya-Hui Hu, Xiao-Peng Lu, Feng Chen
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: The widespread clinical use of lacosamide (LCM) has revealed significant individual differences in clinical response, with various reported influencing factors. However, it remains unclear how genetic factors related to the disposition an
Externí odkaz:
https://doaj.org/article/edea8eaf23be45b2a8e96d57097c7b5f
Autor:
Lin Fan, Hong-Li Guo, Yue-Tao Zhao, Yue Li, Wei-Jun Wang, Jian Huang, Ya-Hui Hu, Ji-Jun Zou, Feng Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe main challenges faced when using sirolimus in children with vascular anomalies (VAs) still include significant pharmacokinetic (PK) variability, uncertainty in the target concentration range, as well as inconsistencies in initial dosing
Externí odkaz:
https://doaj.org/article/433b4c0b159c4248a83f4110a39c4502
Autor:
Hong-Li Guo, Dan-Dan Wu, Di Fu, Yue Li, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Wei-Rong Fang, Jing Xu, Ya-Hui Hu, Qian-Qi Liu, Feng Chen
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to in
Externí odkaz:
https://doaj.org/article/6b1769d95e25434d89723d5330a28112
Autor:
Yue Li, Hong‐Li Guo, Ya‐Hui Hu, Jie Wang, Yuan‐Yuan Zhang, Jian Huang, Jing Xu, Jing Chen, Xiao‐Peng Lu, Feng Chen
Publikováno v:
Epilepsia Open, Vol 9, Iss 1, Pp 268-277 (2024)
Abstract Objective To evaluate the effectiveness and safety of perampanel (PER) monotherapy (MT) or add‐on therapy (AT) in Chinese children with epilepsy, as well as to evaluate the data from routine therapeutic drug monitoring (TDM) of PER for the
Externí odkaz:
https://doaj.org/article/5251273689364f5d99dad4d598d98f76
Autor:
Ya-Hui Hu, Yue-Tao Zhao, Hong-Li Guo, Yue Li, Yuan-Yuan Zhang, Jie Wang, Xuan-Sheng Ding, Ji-Jun Zou, Feng Chen
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1255 (2024)
Objectives: Sirolimus (SRL), a mammalian target of rapamycin inhibitor, has been widely used to treat patients with vascular anomalies (VAs). The objectives of this study were to summarize the routine blood SRL monitoring data for VAs children, to in
Externí odkaz:
https://doaj.org/article/6240a2ac60514d30a5f63ee978cf8783
Autor:
Hong‐Li Guo, Wei‐Jun Wang, Na Dong, Yue‐Tao Zhao, Hao‐Ran Dai, Ya‐Hui Hu, Yuan‐Yuan Zhang, Jie Wang, Jin‐Chun Qiu, Xiao‐Peng Lu, Feng Chen
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 466-478 (2023)
Abstract Objective The drug‐refractory epilepsy (DRE) in children is commonly observed but the underlying mechanisms remain elusive. We examined whether fatty acids (FAs) and lipids are potentially associated with the pharmacoresistance to valproic
Externí odkaz:
https://doaj.org/article/fdaea833d17544488f83b832614d2a62
Autor:
Yue Li, Na Dong, Yu‐Xin Qin, Hao‐Ran Dai, Ya‐Hui Hu, Yue‐Tao Zhao, Hong‐Li Guo, Yuan‐Yuan Zhang, Jing Chen, Xiao‐Peng Lu, Feng Chen
Publikováno v:
Epilepsia Open, Vol 7, Iss 4, Pp 737-746 (2022)
Abstract Objective This study aimed to investigate the efficacy and tolerability of perampanel (PER) therapy and to optimize a specific plasma reference range for PER in children. Another major aim was to evaluate the potential determinators of PER c
Externí odkaz:
https://doaj.org/article/c8998c27363e4a2b8ca779c5eb240900