Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Honda Naoki"'
Autor:
Yuichiro Yada, Honda Naoki
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The pair-wise observation of the input and target values obtained from the same sample is mandatory in any prediction problem. In the biomarker discovery of Alzheimer’s disease (AD), however, obtaining such paired data is laborious and oft
Externí odkaz:
https://doaj.org/article/206ab0d2be5b4c9e86916965521828ff
Autor:
Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Neuromesodermal progenitor (NMP) cells produce and receive Wnt ligands. Here, the authors show that mutual intercellular exchange of Wnt ligands reduces heterogeneity between NMP cells and makes NMP populations robust to environmental stress.
Externí odkaz:
https://doaj.org/article/dbf569909e2848698b13c9d176e72f9c
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A mathematical model of stem cell homeostasis is presented that comprehensively satisfies hierarchy and neutral competition is presented. The model predicts spontaneous generation of clonal bursts, which is consistent with primate hematopoietic data.
Externí odkaz:
https://doaj.org/article/3a459b26efc544e8aa91d93b3e2f94ec
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281319 (2023)
The last three years have been spent combating COVID-19, and governments have been seeking optimal solutions to minimize the negative impacts on societies. Although two types of testing have been performed for this-follow-up testing for those who had
Externí odkaz:
https://doaj.org/article/aa92335dbd4f462cb4d2662ad5fd0da1
Autor:
Kana Yoshido, Honda Naoki
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105754- (2023)
Summary: The immune system discriminates between harmful and harmless antigens based on past experiences; however, the underlying mechanism is largely unknown. From the viewpoint of machine learning, the learning system predicts the observation and u
Externí odkaz:
https://doaj.org/article/5a37dad2695b4e5aaa01cb4cf8649f14
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Single cell RNA-seq loses spatial information of gene expression in multicellular systems because tissue must be dissociated. Here, the authors show the spatial gene expression profiles can be both accurately and robustly reconstructed by a new compu
Externí odkaz:
https://doaj.org/article/abbd231b7f69497dae153503ce587d0f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Collective cell migration is a fundamental process in embryonic development and tissue homeostasis. This is a macroscopic population-level phenomenon that emerges across hierarchy from microscopic cell-cell interactions; however, the underly
Externí odkaz:
https://doaj.org/article/a1f36c1201644cd48beb2191533f33ab
Autor:
Tetsuya Takano, Mengya Wu, Shinichi Nakamuta, Honda Naoki, Naruki Ishizawa, Takashi Namba, Takashi Watanabe, Chundi Xu, Tomonari Hamaguchi, Yoshimitsu Yura, Mutsuki Amano, Klaus M. Hahn, Kozo Kaibuchi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Emerging evidence suggests that gut microbiota influences immune function in the brain and may play a role in neurological diseases. Here, the authors offer in vivo evidence from a Drosophila model that supports a role for gut microbiota in modulatin
Externí odkaz:
https://doaj.org/article/499fc341abbe4dc59222498325b5f835
Autor:
Honda Naoki, Ryutaro Akiyama, Dini Wahyu Kartika Sari, Shin Ishii, Yasumasa Bessho, Takaaki Matsui
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006579 (2019)
The reproducibility of embryonic development is remarkable, although molecular processes are intrinsically stochastic at the single-cell level. How the multicellular system resists the inevitable noise to acquire developmental reproducibility constit
Externí odkaz:
https://doaj.org/article/8eb7ed8ff8b6483a8bf56ca4672a1dcf
Autor:
Shoichiro Yamaguchi, Honda Naoki, Muneki Ikeda, Yuki Tsukada, Shunji Nakano, Ikue Mori, Shin Ishii
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 5, p e1006122 (2018)
Animals are able to reach a desired state in an environment by controlling various behavioral patterns. Identification of the behavioral strategy used for this control is important for understanding animals' decision-making and is fundamental to diss
Externí odkaz:
https://doaj.org/article/3fa74daec59c4688af2a09f5544288fa