Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Honda Naoki"'
Autor:
Yuichiro Yada, Honda Naoki
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The pair-wise observation of the input and target values obtained from the same sample is mandatory in any prediction problem. In the biomarker discovery of Alzheimer’s disease (AD), however, obtaining such paired data is laborious and oft
Externí odkaz:
https://doaj.org/article/206ab0d2be5b4c9e86916965521828ff
Autor:
Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Neuromesodermal progenitor (NMP) cells produce and receive Wnt ligands. Here, the authors show that mutual intercellular exchange of Wnt ligands reduces heterogeneity between NMP cells and makes NMP populations robust to environmental stress.
Externí odkaz:
https://doaj.org/article/dbf569909e2848698b13c9d176e72f9c
Publikováno v:
In Signal Processing July 2023 208
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A mathematical model of stem cell homeostasis is presented that comprehensively satisfies hierarchy and neutral competition is presented. The model predicts spontaneous generation of clonal bursts, which is consistent with primate hematopoietic data.
Externí odkaz:
https://doaj.org/article/3a459b26efc544e8aa91d93b3e2f94ec
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281319 (2023)
The last three years have been spent combating COVID-19, and governments have been seeking optimal solutions to minimize the negative impacts on societies. Although two types of testing have been performed for this-follow-up testing for those who had
Externí odkaz:
https://doaj.org/article/aa92335dbd4f462cb4d2662ad5fd0da1
Autor:
Kana Yoshido, Honda Naoki
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105754- (2023)
Summary: The immune system discriminates between harmful and harmless antigens based on past experiences; however, the underlying mechanism is largely unknown. From the viewpoint of machine learning, the learning system predicts the observation and u
Externí odkaz:
https://doaj.org/article/5a37dad2695b4e5aaa01cb4cf8649f14
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Single cell RNA-seq loses spatial information of gene expression in multicellular systems because tissue must be dissociated. Here, the authors show the spatial gene expression profiles can be both accurately and robustly reconstructed by a new compu
Externí odkaz:
https://doaj.org/article/abbd231b7f69497dae153503ce587d0f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Collective cell migration is a fundamental process in embryonic development and tissue homeostasis. This is a macroscopic population-level phenomenon that emerges across hierarchy from microscopic cell-cell interactions; however, the underly
Externí odkaz:
https://doaj.org/article/a1f36c1201644cd48beb2191533f33ab
Autor:
Mito, Kanatsu-Shinohara, Honda, Naoki, Takashi, Tanaka, Misako, Tatehana, Takako, Kikkawa, Noriko, Osumi, Takashi, Shinohara
Publikováno v:
Stem Cell Reports. 17(9):1924-1941
A small number of offspring are born from the numerous sperm generated from spermatogonial stem cells (SSCs). However, little is known regarding the rules and molecular mechanisms that govern germline transmission patterns. Here we report that the Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1746133352387280e69a86d2489f00b
http://hdl.handle.net/2433/282099
http://hdl.handle.net/2433/282099
Autor:
Tomoya Nakayama, Miki Tanikawa, Yuki Okushi, Thoma Itoh, Tsuyoshi Shimmura, Michiyo Maruyama, Taiki Yamaguchi, Akiko Matsumiya, Ai Shinomiya, Ying-Jey Guh, Junfeng Chen, Kiyoshi Naruse, Hiroshi Kudoh, Yohei Kondo, Honda Naoki, Kazuhiro Aoki, Atsushi J. Nagano, Takashi Yoshimura
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/26/2023, Vol. 120 Issue 52, p1-9, 18p