Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hon Kit Wong"'
Autor:
Tomoyuki Yamanaka, Hon Kit Wong, Asako Tosaki, Peter O Bauer, Koji Wada, Masaru Kurosawa, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93891 (2014)
In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins containing expanded polyQ stretch form aggregates in neurons. Genetic or RNAi screenings in yeast, C. elegans or Drosophila have identified multiple genes modifyin
Externí odkaz:
https://doaj.org/article/208b97340db849a39bf28664846b4fb4
Autor:
Corina Schneidawind, Johan Jeong, Dominik Schneidawind, In-Suk Kim, Jesús Duque-Afonso, Stephen Hon Kit Wong, Masayuki Iwasaki, Erin H. Breese, James L. Zehnder, Matthew Porteus, Michael L. Cleary
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 832-845 (2018)
Abstract: Genome editing provides a potential approach to model de novo leukemogenesis in primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, ver
Externí odkaz:
https://doaj.org/article/fd68330af4e74c4ca8fe1fad62b29ab2
Data from E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia
Autor:
Michael L. Cleary, Michael C. Bassik, Stephen Hon-Kit Wong, Corina Schneidawind, Jason H. Kurzer, Jue Feng, Michael C. Wei, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
There is limited understanding of how signaling pathways are altered by oncogenic fusion transcription factors that drive leukemogenesis. To address this, we interrogated activated signaling pathways in a comparative analysis of mouse and human leuke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa2306bbeb855d310e6f2c8620a9efa
https://doi.org/10.1158/0008-5472.c.6508719.v1
https://doi.org/10.1158/0008-5472.c.6508719.v1
Autor:
Michael L. Cleary, Michael C. Bassik, Stephen Hon-Kit Wong, Corina Schneidawind, Jason H. Kurzer, Jue Feng, Michael C. Wei, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Supplementary data provide further supportive evidence that E2A-PBX1 binds the regulatory regions of its target genes (Supplementary Figure 1), which are expressed in primary ALLs depending on karyotype (Supplementary Figure 2), and have oncogenic ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272fbee84e4571a1d88402704cfd4ff4
https://doi.org/10.1158/0008-5472.22413468.v1
https://doi.org/10.1158/0008-5472.22413468.v1
Autor:
Michael L. Cleary, Michael C. Bassik, Kathleen M. Sakamoto, Xiangshu Xiao, Justus Duyster, Gunnar Cario, Martin Schrappe, Hee-Don Chae, Michael C. Wei, Li Zhu, Stephen Hon Kit Wong, Johan Jeong, Ziming Weng, Edwin E. Jeng, David W. Morgens, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Dasatinib is a multi-tyrosine kinase inhibitor approved for treatment of Ph+ acute lymphoblastic leukemia (ALL), but its efficacy is limited by resistance. Recent preclinical studies suggest that dasatinib may be a candidate therapy in additional ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a5a232d54f4cb298df8b6f2391088a
https://doi.org/10.1158/0008-5472.c.6510546.v1
https://doi.org/10.1158/0008-5472.c.6510546.v1
Autor:
Michael L. Cleary, Michael C. Bassik, Kathleen M. Sakamoto, Xiangshu Xiao, Justus Duyster, Gunnar Cario, Martin Schrappe, Hee-Don Chae, Michael C. Wei, Li Zhu, Stephen Hon Kit Wong, Johan Jeong, Ziming Weng, Edwin E. Jeng, David W. Morgens, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Unbiased shRNA library screening and global transcriptome analyses reveal mechanisms that modulate dasatinib sensitivity and suggest therapeutic strategies to improve outcome of patients with acute lymphoblastic leukemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fd1c5d294edc7195dfdda333c4730d
https://doi.org/10.1158/0008-5472.22420047.v1
https://doi.org/10.1158/0008-5472.22420047.v1
Autor:
Laurie LeBrun, Kristina Danga, Michelle Slade, Jinyi Zhu, Joel W Thompson, Gang Lu, Xinde Zheng, Mary E Matyskiela, Philip P Chamberlain, Hon Kit Wong, Mark Labow, Thomas Clayton, Joshua M. Baughman
Publikováno v:
ACS chemical biology. 15(12)
There is a growing interest in using targeted protein degradation as a therapeutic modality in view of its potential to expand the druggable proteome. One avenue to using this modality is via molecular glue based Cereblon E3 Ligase Modulating Drug co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e730ceac2f8ebc32ff4703e3145e2c
https://pubmed.ncbi.nlm.nih.gov/33206504
https://pubmed.ncbi.nlm.nih.gov/33206504
Autor:
Andus Hon-Kit Wong, Robert E. Drolet, Galya Vassileva, Cheryl A. Gretzula, Paige Cramer, Jyoti Disa, Marija Tadin-Strapps, David J. Stone, Bhavya Voleti, Sarah Jinn, Dawn Toolan
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2389-2394
Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18fc109c991ebfd1af11dfbf9d4505
https://doi.org/10.1073/pnas.1616332114
https://doi.org/10.1073/pnas.1616332114
Autor:
Jesús, Duque-Afonso, Chiou-Hong, Lin, Kyuho, Han, David W, Morgens, Edwin E, Jeng, Ziming, Weng, Johan, Jeong, Stephen Hon Kit, Wong, Li, Zhu, Michael C, Wei, Hee-Don, Chae, Martin, Schrappe, Gunnar, Cario, Justus, Duyster, Xiangshu, Xiao, Kathleen M, Sakamoto, Michael C, Bassik, Michael L, Cleary
Publikováno v:
Cancer research. 78(22)
Dasatinib is a multi-tyrosine kinase inhibitor approved for treatment of Ph+ acute lymphoblastic leukemia (ALL), but its efficacy is limited by resistance. Recent preclinical studies suggest that dasatinib may be a candidate therapy in additional ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10f917611819fc86fae5253e0ad152f5
https://pubmed.ncbi.nlm.nih.gov/30262461
https://pubmed.ncbi.nlm.nih.gov/30262461
Autor:
Rachid El Fatimy, Athul Mohan, Anna M. Krichevsky, Erik J. Uhlmann, Sindhuja Gowrisankaran, Ming Yi, Eric G. Marcusson, Hiroaki Wakimoto, Bakhos A. Tannous, Robert M. Stephens, Priya Karmali, Hon Kit Wong, Courtney Onodera, Jun S. Song, Zhiyun Wei
Publikováno v:
Molecular Therapy. 23(7):1234-1247
Using in silico analysis of The Cancer Genome Atlas (TCGA), we identified microRNAs associated with glioblastoma (GBM) survival, and predicted their functions in glioma growth and progression. Inhibition of two “risky” miRNAs, miR-148a and miR-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95489536c628c6f1bb1d4f0e4bb52a85