Pd-Catalyzed Indolization/peri-C–H Annulation/N-Dealkylation Cascade to Cyclopenta-Fused Acenaphtho[1,2-b]indole Scaffold

Autor: Hidenori Matsuyama, Shin Suzuki, Hon Eong Ho, Masahiro Terada, Masaki Kawata, Tienan Jin

Publikováno v: Organic Letters. 23:9431-9435

A novel Pd-catalyzed cascade reaction of N,N-dialkyl-substituted o-alkynylanilines involving an indolization/peri-C-H annulation/N-dealkylation sequence has been developed to construct a cyclopenta-fused acenaphtho[1,2-b]indole (ANI) scaffold. A vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92cce9a3433f6e7682a55ed4f396d038
https://doi.org/10.1021/acs.orglett.1c03575

Indole Synthesis Using Silver Catalysis

Autor: Richard J. K. Taylor, Aimee K. Clarke, William P. Unsworth, Hon Eong Ho, James A. Rossi-Ashton

Publikováno v: Chemistry – An Asian Journal. 14:1900-1911

Indoles are amongst the most important class of heteroaromatics in organic chemistry, being commonly found in biologically active natural products and therapeutically useful compounds. The synthesis of indoles is therefore important and several metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e123fa8e15f9e4a0c30b1d05a242e59c
https://doi.org/10.1002/asia.201900309

Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones

Autor: Peter O'Brien, Hon Eong Ho, Michael J. James, Ryan G. Epton, James R. Donald, James A. Rossi-Ashton, Angela Pagano, William P. Unsworth, Jonathan C. Churchill, Richard J. K. Taylor

Publikováno v: Chemical Science
Ho, H E, Pagano, A, Rossi-ashton, J A, Donald, J R, Epton, R G, Churchill, J C, James, M J, O'brien, P, Taylor, R J K & Unsworth, W P 2019, ' Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones ', Chemical Science, vol. 11, no. 5, pp. 1353-1360 . https://doi.org/10.1039/C9SC05311E

Indole-tethered ynones form an intramolecular electron donor–acceptor complex that can undergo visible-light-induced charge transfer to promote thiyl radical generation from thiols. This initiates a novel radical chain sequence, based on dearomatis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e1d1028c891c2723beb56e6170668
https://eprints.whiterose.ac.uk/157506/1/c9sc05311e.pdf

Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones : Total Synthesis of Indolizidine 209D

Autor: Michael J. James, William P. Unsworth, Richard J. K. Taylor, Peter O'Brien, Hon Eong Ho

An efficient Ag(I)-catalyzed π-acid activation method for the cyclization of cyclic ketimine-tethered ynones is reported. Various nitrogen-containing scaffolds commonly found in bioactive alkaloids can be prepared in high yields, and the utility of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d854daf0b7da4277c19d6b82bfce54
https://eprints.whiterose.ac.uk/127390/1/Ho_ketimines_paper_version_10_revised_version_.docx

Carboxylic Acid-Catalyzed Highly Efficient and Selective Hydroboration of Alkynes with Pinacolborane

Autor: Tienan Jin, Yoshinori Yamamoto, Naoki Asao, Hon Eong Ho

Publikováno v: Organic Letters. 16:4670-4673

We have demonstrated for the first time that carboxylic acids are able to catalyze the direct hydroboration of various terminal and internal alkynes with pinacolborane without using any metal catalysts. This unprecedented catalytic hydroboration exhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ad6b790bb345d87b8cfd4dafdf83b6
https://doi.org/10.1021/ol502285s