Zobrazeno 1 - 10
of 2 277
pro vyhledávání: '"Homology Modelling"'
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 7, Pp 288-297 (2024)
Objective: To examine the hepatoprotective effects of gedunin in streptozotocin (STZ)-induced diabetic rats. Methods: Rats were divided into 4 groups: control, STZ, gedunin, and STZ+gedunin. Biochemical parameters for liver function and liver histolo
Externí odkaz:
https://doaj.org/article/774f79fcbbd84aa3a3cfe3f9ee4908f2
Autor:
Mahmood Rasool, Peter Natesan Pushparaj, Absarul Haque, Ayat Mohammed Shorbaji, Loubna Siraj Mira, Sherin Bakhashab, Mohamed Nabil Alama, Muhammad Farooq, Sajjad Karim, Lars Allan Larsen
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37177- (2024)
Background & aim: Congenital heart disease (CHD) is the most common cause of non-infectious deaths in infants worldwide. However, the molecular mechanisms underlying CHD remain unclear. Approximately 30 % of the causes are believed to be genetic muta
Externí odkaz:
https://doaj.org/article/457a87b4a9304fe2848619c2131c0d6d
Publikováno v:
Environment Conservation Journal, Vol 25, Iss 3 (2024)
Widespread usage of antifungals has led to the development of antifungal resistance, causing a change in the epidemiology of the responsible agents from albicans to non-Candida albicans species. Pharmaceutical repurposing is an alternate strategy tha
Externí odkaz:
https://doaj.org/article/f7811a6503b0474e8f3db0e5cb01dd39
Autor:
Mousumi Shyam, Abhishek Thakur, Caroline Velez, Chris Daniel, Orlando Acevedo, Sanjib Bhakta, Venkatesan Jayaprakash
Publikováno v:
Frontiers in Antibiotics, Vol 3 (2024)
IntroductionIn response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Inter
Externí odkaz:
https://doaj.org/article/e0ba094b968c42ef87eafcf5d71e033f
Autor:
Bharath Basavapattana Rudresh, Abhishek Kumar Tater, Vaibav Barot, Nitin Patel, Ashita Desai, Sreerupa Mitra, Abhay Deshpande
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e29756- (2024)
The intricate network of glands and organs that makes up the endocrine system. Hormones are used to regulate and synchronize the nervous and physiological systems. The agents which perturbate an endocrine system are called endocrine disruptors and th
Externí odkaz:
https://doaj.org/article/d082bcd2e5ae44a08ab8ae83243258a5
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Permeability-glycoprotein (P-gp) belongs to the ABS transporter protein family, with a high expression rate in cancerous cells. The substrate/inhibitors of the protein are structurally diverse, with no lucid mechanism of inhibition. There are two sch
Externí odkaz:
https://doaj.org/article/1005948909c74bdda46e8e7e3329044d
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101482- (2024)
Wnt signaling is a critical pathway involved in cell proliferation, differentiation and cellular homeostasis. To address treatment need of diseases associated with the dysregulated Wnt signaling like cancer, Alzheimer’s disease, Osteoporosis, Myoca
Externí odkaz:
https://doaj.org/article/394ebf730598485fa2f11d8c9f7b5045
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Arsenic, a ubiquitous toxic metalloid, is a threat to the survival of all living organisms. Bioaccumulation of arsenic interferes with the normal physiological pathway. To overcome arsenic toxicity, organisms have developed arseni
Externí odkaz:
https://doaj.org/article/25366bf90cbb4fbe8d886f9c47fc782f
Autor:
Marialuigia Fantacuzzi, Ilaria D’Agostino, Simone Carradori, Francesco Liguori, Fabrizio Carta, Mariangela Agamennone, Andrea Angeli, Filomena Sannio, Jean-Denis Docquier, Clemente Capasso, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Vibrio cholerae causes life-threatening infections in low-income countries due to the rise of antibacterial resistance. Innovative pharmacological targets have been investigated and carbonic anhydrases (CAs, EC: 4.2.1.1) encoded by V. cholerae (VchCA
Externí odkaz:
https://doaj.org/article/2b2ee7385c74438ea7ee86320973175f
Autor:
Vijai Malik, Faiza Mohamad Ikram, Yogita Singh, Vivek Kumar, Pranita Malik, Priyanka Balyan, Krishna Pal Singh, Reyazul Rouf Mir, Abeer Hashem, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd_Allah, Upendra Kumar
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
The 26S proteasome is a molecular machine that catalyzes and degrades protein intracellularly with the help of its core complex called 20S proteasome. The 20S proteasomes degrade and cleave denatured, cytotoxic, damaged, and unwanted proteins via pro
Externí odkaz:
https://doaj.org/article/6e177690de5a486f865f7bac284206d0