Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Homogeneously Staining Region"'
Autor:
Shohei Mizuno, Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Jo Kanasugi, Ayano Nakamura, Souichi Takasugi, Kaori Uchino, Tomohiro Horio, Mineaki Goto, Satsuki Murakami, Mayuko Gotou, Hidesuke Yamamoto, Masaya Watarai, Masato Shikami, Yoshitaka Hosokawa, Hiroshi Miwa, Masafumi Taniwaki, Ryuzo Ueda, Masakazu Nitta, Akiyoshi Takami
Publikováno v:
FEBS Open Bio, Vol 8, Iss 12, Pp 1977-1991 (2018)
Chromosome band 8q24 is the most frequently amplified locus in various types of cancers. MYC has been identified as the primary oncogene at the 8q24 locus, whereas a long noncoding gene, PVT1, which lies adjacent to MYC, has recently emerged as anoth
Externí odkaz:
https://doaj.org/article/fce41036b929420d9e501181a4ef1468
Autor:
Masakazu Nitta, Mayuko Gotou, Ayano Nakamura, Hidesuke Yamamoto, Yoshitaka Hosokawa, Shohei Mizuno, Mineaki Goto, Ichiro Hanamura, Hiroshi Miwa, Tomohiro Horio, Kaori Uchino, Souichi Takasugi, Jo Kanasugi, Sivasundaram Karnan, Akinobu Ota, Masato Shikami, Masafumi Taniwaki, Satsuki Murakami, Akiyoshi Takami, Masaya Watarai, Ryuzo Ueda
Publikováno v:
FEBS Open Bio
Chromosome band 8q24 is the most frequently amplified locus in various types of cancers. MYC has been identified as the primary oncogene at the 8q24 locus, whereas a long noncoding gene, PVT1, which lies adjacent to MYC, has recently emerged as anoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12303a3e9e7d26b8b7ce22f8f4bc35c8
http://europepmc.org/articles/PMC6275272
http://europepmc.org/articles/PMC6275272
Autor:
Noriaki Shimizu
Publikováno v:
Genes, Vol 12, Iss 1533, p 1533 (2021)
Genes
Genes
Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred to as cytogenetically visible double minutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f203230edda5deca64e03ea875f55bc9
https://www.mdpi.com/2073-4425/12/10/1533
https://www.mdpi.com/2073-4425/12/10/1533
Autor:
Carlos E. Bueso-Ramos, Yang O. Huh, L. Jeffrey Medeiros, Ali Sakhdari, Chi Young Ok, Zhenya Tang
Publikováno v:
Cancer Genetics. 238:18-22
AML and MDS are most common myeloid neoplasms that affect mainly older patients. Overexpression of certain proto-oncogenes plays an indispensable role in tumorigenesis and overexpression can be a consequence of gene rearrangement, amplification and/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da477e74910e3f94ec9bbd5f4929e7ec
https://doi.org/10.1016/j.cancergen.2019.07.001
https://doi.org/10.1016/j.cancergen.2019.07.001
Autor:
Hiroko Ikeda, Takeru Oyama, Yoh Dobashi, Shin-ichi Horike, Satoko Ishikawa, Masafumi Inokuchi, Ritsuko Nakamura, Hiroko Kawashima, Akishi Ooi
Publikováno v:
Human Pathology. 85:33-43
Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b202dd6348562249cc728e16501b90
https://doi.org/10.1016/j.humpath.2018.10.017
https://doi.org/10.1016/j.humpath.2018.10.017
Autor:
Milbrandt, Jeffrey D., Heintz, Nicholas H., White, W. Carlton, Rothman, Steven M., Hamlin, Joyce L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1981 Oct 01. 78(10), 6043-6047.
Externí odkaz:
https://www.jstor.org/stable/11002
Autor:
Dolnick, Bruce J., Berenson, Ronald J., Bertino, Joseph R., Kaufman, Randal J., Nunberg, Jack H., Schimke, Robert T.
Publikováno v:
The Journal of Cell Biology, 1979 Nov 01. 83(2), 394-402.
Externí odkaz:
https://www.jstor.org/stable/1608960
Autor:
Bhushan Thakur, Kazuho Ishine, Noriaki Shimizu, Mirit I. Aladjem, Ryonosuke Taniguchi, Koichi Utani
Publikováno v:
The Journal of Biological Chemistry
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697d87c6d27734a17d75a753638578c9
https://pubmed.ncbi.nlm.nih.gov/33539925
https://pubmed.ncbi.nlm.nih.gov/33539925
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Publikováno v:
Leukemia & Lymphoma. 58:1250-1253
Gene amplification is one mechanism by which oncogenes are overexpressed. Although MLL (KMT2A) gene rearrangements (or 11q23 rearrangements) are well known in acute myeloid leukemia (AML), MLL gene...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1239980ea30e4554c22869b3b35419
https://doi.org/10.1080/10428194.2016.1233539
https://doi.org/10.1080/10428194.2016.1233539