Identification of common genetic variation that modulates alternative splicing

Autor: Julian C. Knight, Martin S. Taylor, Dominic P. Kwiatkowski, Kate Rowlands, Jeremy Hull, Man-Suen Chan, Richard R. Copley, Susana Campino, Gareth Elvidge, Kirk A. Rockett, Brendan J. Keating

Publikováno v: PLoS Genetics
Hull, J, Campino, S, Rowlands, K, Chan, M-S, Copley, R R, Taylor, M S, Rockett, K, Elvidge, G, Keating, B, Knight, J & Kwiatkowski, D 2007, ' Identification of common genetic variation that modulates alternative splicing ', PLoS Genetics, vol. 3, no. 6, pp. e99 . https://doi.org/10.1371/journal.pgen.0030099
PLoS Genetics, Vol 3, Iss 6, p e99 (2007)

Alternative splicing of genes is an efficient means of generating variation in protein function. Several disease states have been associated with rare genetic variants that affect splicing patterns. Conversely, splicing efficiency of some genes is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7898b3b0447ea7b9e0bff9d1ef4132de
https://doi.org/10.1371/journal.pgen.0030099

Lymphotoxin-α gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study

Autor: Robert Clarke, Peng Xu, Derrick Bennett, Sarah Lewington, Krina Zondervan, Sarah Parish, Alison Palmer, Sarah Clark, Lon Cardon, Richard Peto, Mark Lathrop, Rory Collins, International Study of Infarct Survival (ISIS) Collaborators

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 2, Iss 7, p e107 (2006)

Lymphotoxin-α (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc30255e787231928125ca2691d42928
https://ora.ox.ac.uk/objects/uuid:d168a262-7417-4602-8abb-80ea614e4f39

Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women

Autor: Kenneth S. Kendler, Sam X. Chen, Michael Conlon O'Donovan, Nicholas John Craddock, F. Anthony O'Neill, Jonathan Flint, Tao Li, Michal Bronstein, David A. Collier, Martina Johannesson, Daniel R. Weinberger, Ariel Darvasi, Cuie Sun, Dermot Walsh, Sagiv Shifman, Michael John Owen

Publikováno v: Shifman, S, Johannesson, M, Bronstein, M, Chen, S X, Collier, D A, Craddock, N J, Kendler, K S, Li, T, O'Donovan, M, O'Neill, F, Owen, M J, Walsh, D, Weinberger, D R, Sun, C, Flint, J & Darvasi, A 2008, ' Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women ', PLoS Genetics, vol. 4, no. 2, e28 . https://doi.org/10.1371/journal.pgen.0040028
PLoS Genetics
PLoS Genetics, Vol 4, Iss 2, p e28 (2008)

Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific associatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6b73fe0d03c7969bdaa25e5f8fff1e
https://doi.org/10.1371/journal.pgen.0040028

A Phylogenomic Study of Human, Dog, and Mouse

Autor: Gerton Lunter

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 3, Iss 4, p e74 (2007)

In a recent contribution to PLoS Computational Biology, Cannarozzi, Schneider, and Gonnet published evidence that rodents form an outgroup to human and dog [1], in disagreement with several recent studies suggesting that the dog is an outgroup to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074509726c255b3013d828a089643c44
https://doi.org/10.1371/journal.pcbi.0030074

Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells

Autor: Thomas J. Hope, Omar Perez, Masahiro Yamashita, Michael Emerman

Publikováno v: PLoS Pathogens, Vol 3, Iss 10, Pp 1502-1510 (2007)
PLoS Pathogens

HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7224d97cbd99ed9d28c6446880a451d
http://europepmc.org/articles/PMC2042020?pdf=render