MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice

Autor: Polytarchou, C, Hommes, DW, Palumbo, T, Hatziapostolou, M, Koutsioumpa, M, Koukos, G, van der Meulen-de Jong, AE, Oikonomopoulos, A, van Deen, WK, Vorvis, C, Serebrennikova, OB, Birli, E, Choi, J, Chang, L, Anton, PA, Tsichlis, PN, Pothoulakis, C, Verspaget, HW, Iliopoulos, D

Publikováno v: Polytarchou, C; Hommes, DW; Hommes, DW; Palumbo, T; Hatziapostolou, M; Koutsioumpa, M; et al.(2015). MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. Gastroenterology. doi: 10.1053/j.gastro.2015.05.057. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6c5661g0

© 2015 AGA Institute. Background & Aims: Persistent activation of the inflammatory response contributes to the development of inflammatory bowel diseases, which increase the risk of colorectal cancer. We aimed to identify microRNAs that regulate inf

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http://www.escholarship.org/uc/item/6c5661g0

Ustekinumab induction and maintenance therapy in refractory Crohn's disease

Autor: Sandborn, Wj, Gasink, C, Gao, Ll, Blank, Ma, Johanns, J, Guzzo, C, Sands, Be, Hanauer, Sb, Targan, S, Rutgeerts, P, Ghosh, S, de Villiers WJ, Panaccione, R, Greenberg, G, Schreiber, S, Lichtiger, S, Feagan, Bg, Haas, T, Kaser, A, Vogelsang, H, Brown, S, Florin, T, Gibson, Pg, Hetzel, D, Leong, R, Pavli, P, Radford-Smith, G, Sparrow, M, Baert, F, D'Haens, G, D'Heygere, F, Franchimont, D, Louis, E, Mana, F, Moreels, T, Vermeire, S, Anderson, F, Axler, J, Greenbloom, S, Bitton, A, Fedorak, Rn, Larkai, E, Marshall, J, Singh, R, Abitbol, V, Allez, M, Lemann, M, Bonaz, B, Colombel, Jf, Dupas, Jl, Hebuterne, X, Laharie, D, Lerebours, E, Moreau, J, Bokemeyer, B, Holler, B, Howaldt, Sp, Krummenerl, T, Kucharzik, T, Ochsenkühn, T, Raedler, A, Schiefke, I, Seidler, U, Sturm, A, Zeitz, M, Eliakim, A, Fishman, S, Konikoff, Fm, Lavy, A, Niv, Y, Nussinson, E, Rachmilewitz, D, Andriulli, A, Annese, V, Biancone, L, Corazza, Gr, Danese, S, Sturniolo, Gc, Terrosu, G, Sorrentino, D, Hommes, Dw, Jansen, Jm, Otten, Mh, Pierik, M, Ponsioen, Cy, Stokkers, P, van Bodegraven AA, Van der Woude, J, Calvet Calvo, X, Casellas, F, Garcia López, S, Garcia-Planella, E, Ginard-Vincens, D, López San Román, A, Muñoz Nuñez, F, Pérez Gisbert, J, Vera, Mi, Rodrigo, J, Riestra-Menendez, S, Arnott, I, Bloom, S, Campbell, Ss, Harbord, Mw, Mansfield, Jc, Nwokolo, C, Parkes, M, Probert, Cs, Aberra, Fn, Abraham, Bp, Abreu, Mt, Amontree, Js, Barish, Cf, Barto, Ae, Behm, B, Birbara, Ca, Bologna, S, Dryden GW Jr, Eisner, Ms, Ertan, A, Fogel, R, Gagneja, Hk, Ginsburg, P, Goff, Js, Gordon, G, Hamilton, Jw, Hanson, Js, Hardi, R, Hemaidan, A, Higgins, P, Holderman, W, Hornbuckle, K, Ibegbu, E, Isaacs, Kl, Katz, Ja, Katz, S, Kaufman, Bp, Kavanaugh, Af, Khurana, Sk, Lashner, B, Lawrence, S, Hansen, Rn, Lee, S, Leighton, Ja, Leman, Bi, Levenson, Sd, Lowe, Je, Marcuard, Sp, Matsuyama, Rm, Mcnair, Ae, Melmed, G, Miller, Km, Miner PB Jr, Mutlu, Ea, Keshavarzian, A, Narayen, V, Noar, Md, Patel, Ph, Patrick, Tj, Peck, A, Peterson, Ka, Phillips, Rw, Picco, Mf, Randall, C, Richards, Rj, Safdi, Ma, Scherl, Eh, Schwartz, Da, Schwartz, Hi, Schwartz, Jl, Sedghi, S, Shafran, I, Siegel, Ca, Sninsky, Ca, Stern, M, Suiter, D, Swaminath, A, Terdiman, Jp, Mahadevan, U, Thomson, C, Valentine, J, Vasudeva, R, Vecchio, Ja, Wolf, Dc, Yajnik, V, Yabkowski, J, Yen, E.

Publikováno v: New England journal of medicine, 367(16), 1519-1528. Massachussetts Medical Society
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

BACKGROUND In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against interleukin-12 and interleukin-23, is unknown. METHODS We evaluated ustekinumab in adults with moderate-to-severe Crohn's disease that was r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61da68785d51749a18aadbbf4b6659fb
https://pure.amc.nl/en/publications/ustekinumab-induction-and-maintenance-therapy-in-refractory-crohns-disease(84ddd6f0-9401-4834-97b2-0878006f55e3).html

Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk (vol 105, pg 395, 2010)

Autor: Festen, EAM, Stokkers, PCF, van Diemen, CC, van Bodegraven, AA, Boezen, HM, Crusius, BJA, Hommes, DW, van der Woude, C.J., Balschun, T, Verspaget, HW, Schreiber, S, de Jong, DJ, Franke, A, Dijkstra, G, Wijmenga, C, Weersma, RK

Publikováno v: American Journal of Gastroenterology, 105(2), 479-479. Springer Nature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c0cc9db65ff6a263a11a4be0e4da3aa9
https://pure.eur.nl/en/publications/d12ee94b-4076-4847-aba7-435425f49a1d

Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients

Autor: Hawinkels, LJAC, Verspaget, HW, van Duijn, W, van der Zon, JM, Zuidwijk, K, Kubben, FJGM, Verheijen, JH, Hommes, DW, Lamers, CBHW, Sier, CFM

Publikováno v: British journal of cancer, vol 97, iss 3

Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::89f154156cd5195b7c5eb6a11f0551ea
https://escholarship.org/uc/item/5j70f1f4

Microbiële patroonherkenning bij de ziekte van Crohn (microbial pattern recognition in Crohn's disease)

Autor: Lierop, Pieter, Detkova, Z, Hommes, DW, Kuipers, Ernst, Samsom, Janneke, Nieuwenhuis, EES

Publikováno v: Ned. Tijdschrift voor Allergie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5ab807f09f56c9afb68c528224a241fb
https://pure.eur.nl/en/publications/45acea24-8302-4793-8a96-4134b3584669