STEM-17. NOT ALL GBM STEM CELLS ARE EQUAL: IMPLICATIONS FOR RESEARCH AND THERAPY

Autor: Stephen T. Oh, Albert H. Kim, Jian Campian, Diane Mao, Milan G. Chheda, Arijita Jash, Olga Malkova, Luciano Galdieri, Cameron Brennan

Publikováno v: Neuro Oncol

Glioblastoma (GBM) kills almost all patients within 2 years. A subpopulation of cells, GBM stem cells (GSCs), contributes to treatment resistance and recurrence. A major therapeutic goal is to kill GSCs, but no targeted therapy yet exists. Since thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf55dc3799a32b6d69014eeab146d9
https://europepmc.org/articles/PMC7651708/

A master erythroid regulator gets its own GPS

Autor: Lily Jun Shen Huang, James J. Bieker

Publikováno v: Blood

Erythropoiesis is a complex multistage process that involves differentiation of early erythroid progenitors to enucleated mature red blood cells, in which lineage-specific transcription factors play essential roles. Erythroid Krüppel-like factor (EK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676615b48d8f852a4e595bdae6464796
https://pubmed.ncbi.nlm.nih.gov/32384137

Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma

Autor: Jing Jing Gong, Yan Liang, Aled R. Daniels, Kathreena M Kurian, Yuqi Ren, Beatrice Lander, Antonis Tofias, Paul D. White, Xing Ren, Hannah Barber

Publikováno v: Neuro Oncol
Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
Barber, H, Tofias, A, Lander, B, Daniels, A, Gong, J, Ren, Y, Ren, X, Liang, Y, White, P & Kurian, K M 2021, ' Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma ', Journal of Oncology, vol. 2021, 8819702 . https://doi.org/10.1155/2021/8819702

Introduction. Glioblastoma (GBM) is the most common primary adult brain tumour with a median overall survival (OS) of 12–15 months. Molecular characterization of multiple immunooncology targets in GBM may help target novel immunotherapeutic strateg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387bdefc974f71a9ab7605fdd3ca7530
https://europepmc.org/articles/PMC6789701/

ATRT-24. CELL SURFACE PROTEOME ANALYSIS OF ATRT IDENTIFIES TARGETS FOR IMMUNOTHERAPY

Autor: Allison Cole, Eric Hoffmeyer, Siddhartha Mitra, Olivier Ayrault, Rajeev Vibhakar, Marco Zanini, Anandani Nellan

Publikováno v: Neuro-Oncology

Atypical teratoid rhabdoid tumor (ATRT) is a rare and fast-growing childhood tumor of the brain and spinal cord. While the recent advances in DNA and RNA sequencing have given deep insights into the biology of cancer, about 90% of ATRTs harbor a sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbffceaf6d8926faf9cf34b3db299f3
https://doi.org/10.1093/neuonc/noaa222.023

P04.45 Periarteriolar glioblastoma stem cell niches express bone marrow hematopoietic stem cell niche proteins

Autor: B van der Swaan, Hala Kakar, Remco J. Molenaar, Mohammed Khurshed, Renske Hulsbos, Wikky Tigchelaar, Jill R Wormer, Zbynek Tonar, C. J. F. Van Noorden, Barbara Breznik, Vashendriya V V Hira

BACKGROUND: In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4edc5e8074c56ab83b69a56ae52464d
https://europepmc.org/articles/PMC6144740/