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Fertility protection during chemotherapy treatment by boosting the NAD(P) ⁺ metabolome.

Autor: Ho WJ; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.; The Kinghorn Cancer Centre, St. Vincent's Hospital, Darlinghurst, NSW, Australia., Marinova MB; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Listijono DR; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Bertoldo MJ; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Richani D; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Kim LJ; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Brown A; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Riepsamen AH; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Cabot S; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Frost ER; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Bustamante S; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Kensington, NSW, 2052, Australia., Zhong L; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Kensington, NSW, 2052, Australia., Selesniemi K; Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA., Wong D; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Madawala R; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Marchante M; IVI Foundation, Valencia, Spain.; Department of Pediatrics, Obstetrics and Gynaecology, Faculty of Medicine, University of Valencia, Valencia, Spain., Goss DM; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Li C; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia., Araki T; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8502, Japan., Livingston DJ; Metro International Biotech, Worcester, MA, USA., Turner N; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia., Sinclair DA; Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA., Walters KA; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Homer HA; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.; Christopher Chen Oocyte Biology Laboratory, University of Queensland Centre for Clinical Research, Royal Brisbane & Women's Hospital, Herston, QLD, 4029, Australia., Gilchrist RB; School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia., Wu LE; School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia. lindsay.wu@unsw.edu.au.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 Oct; Vol. 16 (10), pp. 2583-2618. Date of Electronic Publication: 2024 Aug 21.

A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development.

Autor: Ye Y; The Christopher Chen Oocyte Biology Research Laboratory, Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia., Homer HA; The Christopher Chen Oocyte Biology Research Laboratory, Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia. Electronic address: h.homer@uq.edu.au.

Publikováno v: Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113917. Date of Electronic Publication: 2024 Mar 05.