Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Homer‐Vanniasinkam, Shervanthi"'
Objectives Ischaemia modified albumin (IMA) has been used as a marker of myocardial ischaemia but little is known about its production during ischaemia of other tissues. The clinical models of patients with intermittent claudication and major arteria
Externí odkaz:
http://hdl.handle.net/10454/3805
Autor:
Graham, Anne M, Naseem, Khalid M., Oberprieler, Nikolaus G., Riba, Rocio, Roberts, Wayne, Homer-Vanniasinkam, Shervanthi
We examined the influence of S-nitrosoglutathione (GSNO) on alpha(IIb)beta(3) integrin-mediated platelet adhesion to immobilised fibrinogen. GSNO induced a time- and concentration-dependent inhibition of platelet adhesion. Inhibition was cGMP-indepen
Externí odkaz:
http://hdl.handle.net/10454/3313
The expression and potential role of platelet membrane CD154 and sCD154 in atherosclerosis was investigated in patients with peripheral arterial disease. This prospective observational study measured the expression of platelet-bound CD154 and soluble
Externí odkaz:
http://hdl.handle.net/10454/4118
Endothelln-converting enzyme (ECE-1) is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin (ET-1). It has previously been shown that the levels of both ET-1 and ECE-1 are raised in atherosclerosis, but the possible r
Externí odkaz:
http://hdl.handle.net/10454/3922
Objectives It is hypothesised that endothelial cell reactive antibodies (ECRA) play a role in the progression of PAD through activation of endothelial cells and the release of inflammatory cytokines. We aimed to test this hypothesis by assessing leve
Externí odkaz:
http://hdl.handle.net/10454/2888
Elevated plasma concentrations of the sulphur-containing amino acid homocysteine (Hcy) is associated with increased risk of atherosclerosis and arterial thrombosis. The mechanism by which Hcy exerts these effects has yet to be fully elucidated, altho
Externí odkaz:
http://hdl.handle.net/10454/3839
The effects of exercise and warm-up were investigated in patients with claudication. This case-control crossover study involved two treadmill exercise tests, one preceded by a warm-up. Exercise continued until maximal leg pain (patients with claudica
Externí odkaz:
http://hdl.handle.net/10454/4147
Vascular inflammation is implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm (AAA), and is thought to involve reactive species such as the nitric oxide-derived oxidant peroxynitrite. In the present study nitrotyrosine was
Externí odkaz:
http://hdl.handle.net/10454/4094
Background Hyperhomocysteinaemia is an independent risk factor in the development of cardiovascular disease. Although homocysteine has been shown to affect endothelial cell function, the mechanisms by which it induces disease states are still poorly
Externí odkaz:
http://hdl.handle.net/10454/4004