Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Homeodomain Proteins/physiology"'
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91411d9a3772f259276cff0fffa8e
https://doi.org/10.1371/journal.pone.0263430
https://doi.org/10.1371/journal.pone.0263430
Autor:
Muriel Jaquet, Naoyuki Miura, Amélie Sabine, Damien Bebber, René Hägerling, Yan Agalarov, Anna Pfenniger, Tatiana V. Petrova, Brenda R. Kwak, Taija Makinen, Hélène Maby-El Hajjami, Ralf H. Adams, Cathrin Pollmann, Olivier Dormond, Friedemann Kiefer, J. M. Calmes
Publikováno v:
Developmental cell
Developmental Cell, Vol. 22, No 2 (2012) pp. 430-45
Developmental Cell, Vol. 22, No 2 (2012) pp. 430-45
SummaryLymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical forces are not well understood. We found that the transcription factors PROX1 and FOXC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159eeb70fd8a5c2630609591bb8e273b
Autor:
Leanne Toube, Pedro Luis Herrera, Xunlei Zhou, Peter Gruss, Till Marquardt, Asher Berry, Ruth Ashery-Padan
Publikováno v:
Developmental Biology, Vol. 269, No 2 (2004) pp. 479-488
Developmental Biology
Developmental Biology
Pax6 transcription factor is required for islet cell number, morphology, and hormone gene expression. The perinatal lethality of Pax6 null mutants has restricted investigation of the role of Pax6 in normal endocrine cell function. Therefore, we devis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15d39be30f37513feafc2f36943a08
https://doi.org/10.1016/j.ydbio.2004.01.040
https://doi.org/10.1016/j.ydbio.2004.01.040
Publikováno v:
Molecular and Cellular Biology, Vol. 29, No 8 (2009) pp. 2322-2334
Pax6 is important in the development of the pancreas and was previously shown to regulate pancreatic endocrine differentiation, as well as the insulin, glucagon, and somatostatin genes. Prohormone convertase 2 (PC2) is the main processing enzyme in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c5236d1e1c8118fb84053c76a0e1dc
https://europepmc.org/articles/PMC2663301/
https://europepmc.org/articles/PMC2663301/
Autor:
Maedler, Kathrin, Schumann, Desiree, Schulthess, Fabienne, Oberholzer, José, Bosco, Domenico, Berney, Thierry, Donath, Marc Y
Publikováno v:
Diabetes, Vol. 55, No 9 (2006) pp. 2455-62
Type 2 diabetes is characterized by a deficit in beta-cell mass, and its incidence increases with age. Here, we analyzed beta-cell turnover in islets from 2- to 3- compared with 7- to 8-month-old rats and in human islets from 53 organ donors with age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::2cf7ee5e4e4ea12f8b72a0f4a6f1ba72
https://archive-ouverte.unige.ch/unige:36975
https://archive-ouverte.unige.ch/unige:36975
Autor:
Domenico Bosco, Reto M. Baertschiger, Yoichiro Iwakura, Jose Oberholzer, Benoit R. Gauthier, Claes B. Wollheim, Marc Y. Donath, Helga Ellingsgaard, Nadine S. Sauter, Desiree M. Schumann, Kathrin Maedler
Publikováno v:
Diabetes, Vol. 55, No 10 (2006) pp. 2713-22
High glucose concentrations have a dual effect on beta-cell turnover, inducing proliferation in the short-term and apoptosis in the long-term. Hyperglycemia leads to beta-cell production of interleuking (IL)-1beta in human pancreatic islets. Fas, a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af167f76184b62e33f6726df0f74dfa
https://archive-ouverte.unige.ch/unige:34523
https://archive-ouverte.unige.ch/unige:34523
Publikováno v:
Development, Vol. 133, No 10 (2006) pp. 2023-2032
A recent study has shown that deletion of β-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of β-catenin within mouse pancreatic epithelium can have divergent effects on both org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eee0e4e3d253ab3681b86154d1179d
https://archive-ouverte.unige.ch/unige:8801
https://archive-ouverte.unige.ch/unige:8801
Autor:
Duboule Denis
Publikováno v:
The International journal of developmental biology
Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f2a2018b06cac357ca16f6eeb9bd18ee
https://infoscience.epfl.ch/record/167766
https://infoscience.epfl.ch/record/167766