Výsledky vyhledávání - "Homeodomain Proteins/biosynthesis"

Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies

Autor: Ivan Stamenkovic, Miguel Rivera, Angela Volorio, Sowmya Iyer, Liliane C. Broye, Nicolo Riggi, Gaylor Boulay

Publikováno v: Genes & development, vol. 32, no. 15-16, pp. 1008-1019

Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5970a5a72d1ba8518ad231ed454cdb0
https://pubmed.ncbi.nlm.nih.gov/30068701

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Establishment of a developmental compartment requires interactions between three synergistic Cis-regulatory modules

Autor: Paul Schedl, Fisun Hamaratoglu, David Requena, Dimitri Bieli, Carlos Estella, Matthew Slattery, Oguz Kanca, Daryl M. Gohl, Markus Affolter, Martin Müller

Publikováno v: Plos Genetics, vol. 11, no. 10, pp. e1005376
PLoS Genetics, Vol 11, Iss 10, p e1005376 (2015)
PLoS Genetics
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC

The subdivision of cell populations in compartments is a key event during animal development. In Drosophila, the gene apterous (ap) divides the wing imaginal disc in dorsal vs ventral cell lineages and is required for wing formation. ap function as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e43ebfbb4f0711adea81663e64d3c7
https://orca.cardiff.ac.uk/id/eprint/118484/1/journal.pgen.1005376.PDF

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Dynamic expression of transcription factor Brn3b during mouse cranial nerve development

Autor: Sajgo, Szilard, Ali, Seid, Popescu, Octavian, Badea, Tudor Constantin

Publikováno v: Sajgo, S, Ali, S, Popescu, O & Badea, T C 2016, ' Dynamic expression of transcription factor Brn3b during mouse cranial nerve development ' The Journal of Comparative Neurology, vol. 524, no. 5, pp. 1033-61 . https://doi.org/10.1002/cne.23890

During development, transcription factor combinatorial codes define a large variety of morphologically and physiologically distinct neurons. Such a combinatorial code has been proposed for the differentiation of projection neurons of the somatic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0409260372a70eada714dfd9b5823bf3
https://pure.au.dk/portal/da/publications/dynamic-expression-of-transcription-factor-brn3b-during-mouse-cranial-nerve-development(b448f963-7b2e-4357-859d-2af17b695dba).html

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Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice

Autor: Dorothée Caille, Romano Regazzi, E. Roggli, Sonia Gattesco, Christian Boitard, Paolo Meda, Claire Briet

Publikováno v: Diabetes, vol. 61, no. 7, pp. 1742-1751
Diabetes

During the initial phases of type 1 diabetes, pancreatic islets are invaded by immune cells, exposing β-cells to proinflammatory cytokines. This unfavorable environment results in gene expression modifications leading to loss of β-cell functions. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4c5e3ab7c6e1f9ec5e1c622a4a701
https://doi.org/10.2337/db11-1086

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Bat accelerated regions identify a bat forelimb specific enhancer in the HoxD locus

Autor: Walter L. Eckalbar, Jingjing Zhao, Betty M. Booker, Katherine S. Pollard, Nicola Illing, Malcolm Logan, Mandy K. Mason, Nadav Ahituv, Tara Friedrich, Julia E. VanderMeer

Publikováno v: PLOS Genetics
Booker, B M, Friedrich, T, Mason, M K, VanderMeer, J E, Zhao, J, Eckalbar, W L, Logan, M, Illing, N, Pollard, K S & Ahituv, N 2016, ' Bat Accelerated Regions Identify a Bat Forelimb Specific Enhancer in the HoxD Locus ', PL o S Genetics, vol. 12, no. 3, pp. e1005738 . https://doi.org/10.1371/journal.pgen.1005738
PLoS Genetics
PLoS Genetics, Vol 12, Iss 3, p e1005738 (2016)

The molecular events leading to the development of the bat wing remain largely unknown, and are thought to be caused, in part, by changes in gene expression during limb development. These expression changes could be instigated by variations in gene r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b7d3c13dfd52f2547c73b7d6067ac
http://hdl.handle.net/11427/18857

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DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation

Autor: Alexandra Tassin, Isabelle Mahieu, Alexandra Belayew, Dalila Laoudj-Chenivesse, Axelle Leroy, Véronique Mainfroid, Gillian Butler-Browne, Denise A. Figlewicz, Eugénie Ansseau, India Leclercq, Marietta Barro, Céline Vanderplanck, Vincent Mouly, Frédérique Coppée, Aline Marcowycz, Sébastien Sauvage

Publikováno v: PLoS ONE
PLoS ONE, 2009, 4 (10), pp.e7482. ⟨10.1371/journal.pone.0007482⟩
PLoS ONE, Vol 4, Iss 10, p e7482 (2009)
PloS one, 4 (10

Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contractions of the D4Z4 repeat array in 4q35. We have previously identified a double homeobox gene (DUX4) within each D4Z4 unit that encodes a transcription factor express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ab477cc054724968098eda6de32395
https://hal.science/hal-03821134

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Differential expression of LMO4 protein in Alzheimer's disease

Autor: G, Leuba, A, Vernay, D, Vu, C, Walzer, B, Belloir, R, Kraftsik, C, Bouras, A, Savioz

Publikováno v: Neuropathology and Applied Neurobiology, Vol. 30, No 1 (2004) pp. 57-69

The molecular bases of late-onset and sporadic Alzheimer's disease (AD) still have to be unraveled. Among putative candidates for molecular variations in AD, we propose LMO4 protein, a transcription regulator, involved in multiple protein complexes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c4bdd5ba71e605b89a7fcf1c6115537
https://archive-ouverte.unige.ch/unige:26609

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Genetic patterning of the developing mouse tail at the time of posterior neuropore closure

Autor: Gofflot, Françoise Auteur University of Oxford, Hall, M, Morriss-Kay, G M

Posterior neuropore (PNP) closure coincides with the end of gastrulation, marking the end of primary neurulation and primary body axis formation. Secondary neurulation and axis formation involve differentiation of the tail bud mesenchyme. Genetic con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1493::ee16550e21645de9e24195dc024ff219
https://hdl.handle.net/2078/92223

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Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

Autor: Marie-Ange Bonnin, L.A. McNaughton, N M Le Douarin, Robb Krumlauf, Anne Grapin-Botton

Publikováno v: Europe PubMed Central
Scopus-Elsevier

In this study we have analysed the expression of Hoxb-4, Hoxb-1, Hoxa-3, Hoxb-3, Hoxa-4 and Hoxd-4 in the neural tube of chick and quail embryos after rhombomere (r) heterotopic transplantations within the rhombencephalic area. Grafting experiments w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d44f19f62b2a744df4dd19b8d46d5b
http://europepmc.org/abstract/med/7555700

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