T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers

Autor: Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink, Georges M. G. M. Verjans

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)

Abstract Background Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term control of latent HSV-1 infection, but it is unclear whether these cell

Externí odkaz: https://doaj.org/article/7cd9a7aa026e4dcdb0d7747d810f3bd4

Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors

Autor: Jet van denDijssel, Ruth R Hagen, Rivka deJongh, Maurice Steenhuis, Theo Rispens, Dionne M Geerdes, Juk Yee Mok, Angela HM Kragten, Mariël C Duurland, Niels JM Verstegen, S Marieke vanHam, Wim JE vanEsch, Klaas PJM vanGisbergen, Pleun Hombrink, Anja tenBrinke, Carolien E van deSandt

Publikováno v: Clinical & Translational Immunology, Vol 11, Iss 10, Pp n/a-n/a (2022)

Abstract Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated protection are not well understood. The antigenic breadth and the immun

Externí odkaz: https://doaj.org/article/d9b148eb22f04368b74c19967cb566df

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Autor: Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8+ TRM cells within the skin and the small intestine are long-lived and maintained inde

Externí odkaz: https://doaj.org/article/d505b02166104b0ea42a24ef254d41bb

Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study

Autor: Biesbroek, G., Kapitein, B., Kuipers, I.M., Gruppen, M.P., Stijn, D. van, Peros, T.E., Veenendaal, M. van, Jansen, M.H.A., Zee, C.W. van der, Kuip, M. van der, Asmuth, E.G.J. von, Mooij, M.G., Boer, M.E.J. den, Landman, G.W., Houten, M.A. van, Schonenberg-Meinema, D., Furth, A.M.T. van, Hensbroek, M.B. van, Scherpbier, H., Meijgaarden, K.E. van, Ottenhoff, T.H.M., Joosten, S.A., Ketharanathan, N., Blink, M., Brackel, C.L.H., Zaaijer, H.L., Hombrink, P., Berg, J.M. van den, Buddingh, E.P., Kuijpers, T.W.

Publikováno v: PLoS ONE, 17(11 November):e0266336. Public Library of Science
PLoS ONE, 17(11). PUBLIC LIBRARY SCIENCE
Biesbroek, G, Kapitein, B, Kuipers, I M, Gruppen, M P, van Stijn, D, Peros, T E, van Veenendaal, M, Jansen, M H A, van der Zee, C W, van der Kuip, M, von Asmuth, E G J, Mooij, M G, den Boer, M E J, Landman, G W, van Houten, M A, Schonenberg-Meinema, D, Tutu van Furth, A M, Boele van Hensbroek, M, Scherpbier, H, van Meijgaarden, K E, Ottenhoff, T H M, Joosten, S A, Ketharanathan, N, Blink, M, Brackel, C L H, Zaaijer, H L, Hombrink, P, van den Berg, J M, Buddingh, E P & Kuijpers, T W 2022, ' Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children : An observational study ', PLoS ONE, vol. 17, no. 11 November, e0266336 . https://doi.org/10.1371/journal.pone.0266336, https://doi.org/10.371/journal.pone.0266336

Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40f0100a65dd6b764ec67daa2a88933
https://research.vumc.nl/en/publications/48fd000c-ddf0-4550-87bf-0a82392ebfb8

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