Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Homayoun Vaziri"'
Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells.
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e23436 (2011)
Genetic comparison between human embryonic stem cells and induced pluripotent stem cells has been hampered by genetic variation. To solve this problem, we have developed an isogenic system that allows direct comparison of induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/e7c0db1c6a9547c287beb91d31415bc3
Autor:
Walter D. Funk, L Briggs, A Guigova, Lacher, Janani Sampathkumar, J Wheeler, Dana Larocca, Rodolfo Gonzalez, Hal Sternberg, Evan Y. Snyder, Jonathan H. Teichroeb, Karen B. Chapman, Homayoun Vaziri, West, WH Andrews, I Singec, James T Murai
Publikováno v:
Regenerative Medicine. 5:345-363
Aim: To determine whether transcriptional reprogramming is capable of reversing the developmental aging of normal human somatic cells to an embryonic state. Materials & methods: An isogenic system was utilized to facilitate an accurate assessment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58770ae72a1d5074ac9645c69aa4771
https://doi.org/10.2217/rme.10.21
https://doi.org/10.2217/rme.10.21
Publikováno v:
Molecular Biology of the Cell. 20:464-480
Functional proteins of complex eukaryotes within the same species are rather invariant. A single catalytic component of telomerase TERT is essential for an active telomerase complex that maintains telomeres. Surprisingly, we have identified two paral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9afb19cad017422889b1b1adb415680
https://doi.org/10.1091/mbc.e08-07-0748
https://doi.org/10.1091/mbc.e08-07-0748
Autor:
Prerna Prasad, Matthew Coussens, Guanglei Zhang, Trystan B. Wells, Irving L. Weissman, Richard C. Allsopp, Derrick J. Rossi, Homayoun Vaziri, Swami R. Narala
Publikováno v:
Molecular Biology of the Cell. 19:1210-1219
SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-dependent deacetylase implicated in regulation of lifespan. By designing effective short hairpin RNAs and a silent shRNA-resistant mutant SIRT1 in a genetically defined syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee4d64a640eba82426c816241a7b0c0
https://doi.org/10.1091/mbc.e07-09-0965
https://doi.org/10.1091/mbc.e07-09-0965
Autor:
Roy A. Frye, Shin-ichiro Imai, Scott K. Dessain, Tej K. Pandita, Elinor Ng Eaton, Robert A. Weinberg, Leonard Guarente, Homayoun Vaziri
Publikováno v:
Cell. 107:149-159
DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2SIRT1, the human homolog of the S. cerevisiae Sir2 protein known to be involved in cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dbddddfa4b17cd22b3559d0186aea7
https://doi.org/10.1016/s0092-8674(01)00527-x
https://doi.org/10.1016/s0092-8674(01)00527-x
Autor:
Homayoun Vaziri
Publikováno v:
Journal of Anti-Aging Medicine. 1:125-130
Normal human cells have a limited life span in culture, exhaust their replicative potential after a fixed number of doublings, and enter a phase of cell cycle arrest termed "senescence." Senescent cells are metabolically active cells, known to up-reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9247ced70d3ccd8afe2b76f2b61ab7a
https://doi.org/10.1089/rej.1.1998.1.125
https://doi.org/10.1089/rej.1.1998.1.125
Autor:
Yu-Sung Wu, Timothy S. Davison, Michael D. West, Samuel Benchimol, Cheryl H. Arrowsmith, Guy G. Poirier, Homayoun Vaziri, Richard C. Allsopp
Publikováno v:
The EMBO Journal. 16:6018-6033
Telomere loss has been proposed as a mechanism for counting cell divisions during aging in normal somatic cells. How such a mitotic clock initiates the intracellular signalling events that culminate in G1 cell cycle arrest and senescence to restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac59666d5bdbc812d67beab62b97079
https://doi.org/10.1093/emboj/16.19.6018
https://doi.org/10.1093/emboj/16.19.6018
Autor:
Michael C. Kolios, Samuel Benchimol, Michael D. Sherar, John W. Hunt, F. Peter Ottensmeyer, Homayoun Vaziri, Gregory J. Czarnota
Publikováno v:
Ultrasound in Medicine & Biology. 23:961-965
Ultrasonic imaging is frequently used in medical diagnosis to differentiate normal and tumour tissues. Here we investigate if distinct types of cell death can be discriminated through the use of ultrasound biomicroscopy. By using a well-controlled sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60aeed4a226da5b75926a45efd26229
https://doi.org/10.1016/s0301-5629(97)00067-7
https://doi.org/10.1016/s0301-5629(97)00067-7
Autor:
Samuel Benchimol, Homayoun Vaziri
Publikováno v:
Experimental Gerontology. 31:295-301
In the cold winter of 1966 Aleksay Olovnikov, a theoretical biologist at the Academy of Sciences in Moscow, was waiting in the subway station where he was hit by the idea that the ends of linear chromosomes can't be replicated fully during each round
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bdfcf32daa3c976cbb627a6a305aff
https://doi.org/10.1016/0531-5565(95)02025-x
https://doi.org/10.1016/0531-5565(95)02025-x
Publikováno v:
Paediatrics Publications
PLoS ONE
PLoS ONE, Vol 6, Iss 10, p e23436 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 10, p e23436 (2011)
Genetic comparison between human embryonic stem cells and induced pluripotent stem cells has been hampered by genetic variation. To solve this problem, we have developed an isogenic system that allows direct comparison of induced pluripotent stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efafed39827629ab6b726df49584213
https://ir.lib.uwo.ca/context/paedpub/article/1836/viewcontent/17.652.pdf
https://ir.lib.uwo.ca/context/paedpub/article/1836/viewcontent/17.652.pdf
