Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Homare Eda"'
Publikováno v:
JBMR Plus, Vol 6, Iss 11, Pp n/a-n/a (2022)
ABSTRACT Although changes in bone mineral density (BMD) are important indexes in osteoporosis treatment, no markers are available to predict them. Given the importance of assessing the therapeutic windows of antiresorptives, we explored potential bio
Externí odkaz:
https://doaj.org/article/bb6037d30d554ff9a7d8e885b0de6406
Autor:
Noopur Raje, Kenneth C. Anderson, Sylvie M. Guichard, Francesca Cottini, Rikio Suzuki, Hiroto Ohguchi, Yiguo Hu, Gullu Gorgun, Andrew Yee, Anuj Mahindra, Neeharika Nemani, Yuko Mishima, Homare Eda, Teru Hideshima, Loredana Santo, Diana Cirstea
Supplementary Figure 1: U266 cells were transiently transfected with 500 nM of small interfering RNA (siRNA) SMARTpool for IGF1R or nonspecific control duplexes (pool of four; Thermo Scientific Dharmacon) using the Cell Line Nucleofector Kit V Soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693091c87f53c7150667c335c3a494f8
https://doi.org/10.1158/1535-7163.22501549.v1
https://doi.org/10.1158/1535-7163.22501549.v1
Autor:
Noopur Raje, Kenneth C. Anderson, Sylvie M. Guichard, Francesca Cottini, Rikio Suzuki, Hiroto Ohguchi, Yiguo Hu, Gullu Gorgun, Andrew Yee, Anuj Mahindra, Neeharika Nemani, Yuko Mishima, Homare Eda, Teru Hideshima, Loredana Santo, Diana Cirstea
Despite promising preclinical results with mTOR kinase inhibitors in multiple myeloma, resistance to these drugs may arise via feedback activation loops. This concern is especially true for insulin-like growth factor 1 receptor (IGF1R), because IGF1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b5cf68b8a926ad1400d49d888efc85
https://doi.org/10.1158/1535-7163.c.6536824.v1
https://doi.org/10.1158/1535-7163.c.6536824.v1
Publikováno v:
JBMR Plus. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d98230da403f47468f2a5cd63ba642
https://doi.org/10.1002/jbm4.10690
https://doi.org/10.1002/jbm4.10690
Autor:
Janani Ramachandran, Ka Tat Siu, Homare Eda, Andrew Yee, Cristina Panaroni, Loredana Santo, Michael R. Cooper, Jennifer A. Mertz, Robert J. Sims, Noopur Raje
Publikováno v:
Leukemia. 31:1760-1769
Inhibition of the bromodomain and extra-terminal (BET) proteins is a promising therapeutic strategy for various hematologic cancers. Previous studies suggest that BET inhibitors constrain tumor cell proliferation and survival mainly through the suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd08fec0aff40373d57ff96ebf68fdc
https://doi.org/10.1038/leu.2016.355
https://doi.org/10.1038/leu.2016.355
Autor:
David T. Scadden, Homare Eda, Noopur Raje, Janani Ramachandran, Demetrios Kalaitzidis, David B. Sykes, Ying-Hua Wang, Dongjun Lee
Publikováno v:
Journal of Clinical Investigation. 126:1300-1310
Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0505a973e82a1a3a2d4da7a8d65cfef0
https://doi.org/10.1172/jci84620
https://doi.org/10.1172/jci84620
Autor:
Nikhil C. Munshi, Noopur Raje, Stuart Kuhstoss, Homare Eda, Henry M. Kronenberg, Loredana Santo, Yu-Tzu Tai, Diana Cirstea, Dorothy Hu, Sarah E Raines, Neeharika Nemani, Marc N. Wein
Publikováno v:
Journal of Bone and Mineral Research. 31:1225-1234
Sclerostin is a potent inhibitor of osteoblastogenesis. Interestingly, newly diagnosed multiple myeloma (MM) patients have high levels of circulating sclerostin that correlate with disease stage and fractures. However, the source and impact of sclero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b7fc2d1d0327a0ee523d8c6bb05e6b9
https://doi.org/10.1002/jbmr.2789
https://doi.org/10.1002/jbmr.2789
Autor:
Noopur Raje, Neeharika Nemani, Diana Cirstea, Elizabeth O'Donnell, Loredana Santo, Yuko Mishima, Andrew Yee, Chirayu G. Patel, Homare Eda
Publikováno v:
Journal of Bone and Mineral Research. 30:465-470
Decorin is a small, leucine-rich proteoglycan found in the extracellular matrix of various connective tissues with potential effective tumor suppressive properties. Recent data suggest low levels of decorin in multiple myeloma (MM) patients compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68984f1cdb2a48d5f3b73b68b7eaeee
https://doi.org/10.1002/jbmr.2371
https://doi.org/10.1002/jbmr.2371
Autor:
Sylvie Guichard, Yiguo Hu, Andrew Yee, Loredana Santo, Homare Eda, Kenneth C. Anderson, Neeharika Nemani, Rikio Suzuki, Diana Cirstea, Gullu Gorgun, Teru Hideshima, Hiroto Ohguchi, Noopur Raje, Francesca Cottini, Anuj Mahindra, Yuko Mishima
Publikováno v:
Molecular Cancer Therapeutics. 13:2489-2500
Despite promising preclinical results with mTOR kinase inhibitors in multiple myeloma, resistance to these drugs may arise via feedback activation loops. This concern is especially true for insulin-like growth factor 1 receptor (IGF1R), because IGF1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e1078924676d8a25069c75c23268d9
https://doi.org/10.1158/1535-7163.mct-14-0147
https://doi.org/10.1158/1535-7163.mct-14-0147
Autor:
Homare Eda, Yiguo Hu, Noopur Raje, Loredana Santo, Gullu Gorgun, Naoya Mimura, Francesca Cottini, Rikio Suzuki, Kenneth C. Anderson, Hannes Loferer, Hiroto Ohguchi, Diana Cirstea, Neeharika Nemani, Yuko Mishima, Nikhil C. Munshi, Teru Hideshima
Publikováno v:
Leukemia
Small-molecule multi-targeted cyclin-dependent kinase (CDK) inhibitors (CDKIs) are of particular interest due to their potent antitumor activity independent of p53 gene alterations. P53 deletion is associated with a very poor prognosis in multiple my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebaff52248029892897fe1d922eb56a
https://doi.org/10.1038/leu.2013.194
https://doi.org/10.1038/leu.2013.194