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Transforming the oncology data paradigm by creating, capturing, and retrieving structured cancer data at the point of care: A Mayo Clinic pilot.

Autor: Tevaarwerk AJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Karam D; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Gatten CA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Harlos ES; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Maurer MJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Giridhar KV; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Haddad TC; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Alberts SR; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Holton SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Stockham A; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Leventakos K; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Hubbard JM; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Mansfield AS; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Halfdanarson TR; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Chen R; Division of Hematology & Oncology, Mayo Clinic, Jacksonville, Florida, USA., Jochum JA; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Schwecke AS; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Eiring RA; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Carroll JL; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Riaz IB; Division of Hematology & Oncology, Mayo Clinic Comprehensive Cancer Center, Phoenix, Arizona, USA., McWilliams RR; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Galanis E; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Mandrekar SJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Cancer [Cancer] 2024 Apr 25. Date of Electronic Publication: 2024 Apr 25.

Structural modulation of membrane-intercalating conjugated oligoelectrolytes decouples outer membrane permeabilizing and antimicrobial activities.

Autor: Moreland AS; Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA., Limwongyut J; Department of Chemistry, National University of Singapore 117544, Singapore., Holton SJ; Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA., Bazan GC; Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.; Department of Chemistry, National University of Singapore 117544, Singapore.; Department of Chemical and Biomolecular Engineering, National University of Singapore 117544, Singapore. chmbgc@nus.edu.sg.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Oct 10; Vol. 59 (81), pp. 12172-12175. Date of Electronic Publication: 2023 Oct 10.

Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.

Autor: Orsi DL; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ferrara SJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Siegel S; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Friberg A; Nuvisan ICB GmbH, 13353 Berlin, Germany., Bouché L; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Pook E; Research and Development, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany., Lienau P; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Bluck JP; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Akcay G; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Stellfeld T; Nuvisan ICB GmbH, 13353 Berlin, Germany., Meyer H; Nuvisan ICB GmbH, 13353 Berlin, Germany., Pütter V; Nuvisan ICB GmbH, 13353 Berlin, Germany., Holton SJ; Nuvisan ICB GmbH, 13353 Berlin, Germany., Korr D; Nuvisan ICB GmbH, 13353 Berlin, Germany., Jerchel-Furau I; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Pantelidou C; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Strathdee CA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Meyerson M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics and Medicine, Harvard Medical School, Boston, MA 02115, USA., Eis K; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: jgold@broadinstitute.org.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Jan 15; Vol. 78, pp. 117130. Date of Electronic Publication: 2022 Dec 13.