DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

Autor: Watts, George, Futscher, Bernard, Holtan, Nicholas, DeGeest, Koen, Domann, Frederick, Rose, Stephen

BACKGROUND:Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.METHODS:The met

Externí odkaz: http://hdl.handle.net/10150/610037
http://arizona.openrepository.com/arizona/handle/10150/610037

Human Pancreatic Carcinoma Cells Activate Maspin Expression Through Loss of Epigenetic Control1

Autor: Fitzgerald, Matthew, Oshiro, Marc, Holtan, Nicholas, Krager, Kimberly, Cullen, Joseph J, Futschery, Bernard W, Domann, Frederick E

The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis. In other normal human cells and their malignant counterparts, maspin expression is controlled through the epigenetic sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2318d74beb7d0c7aec126ab4a548524
https://europepmc.org/articles/PMC1502613/

Role for DNA methylation in the control of cell type?specific maspin expression.

Autor: Futscher, Bernard W., Oshiro, Marc M., Wozniak, Ryan J., Holtan, Nicholas, Hanigan, Christin L., Duan, Hong, Domann, Frederick E.

Publikováno v: Nature Genetics; Jun2002, Vol. 31 Issue 2, p175, 5p

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage.

Autor: Watts GS; Department of Medical Pharmacology, College of Medicine, University of Arizona, Tucson AZ 85724 USA. gwatts@azcc.arizona.edu, Futscher BW, Holtan N, Degeest K, Domann FE, Rose SL

Publikováno v: BMC medical genomics [BMC Med Genomics] 2008 Sep 30; Vol. 1, pp. 47. Date of Electronic Publication: 2008 Sep 30.

Role for DNA methylation in the control of cell type specific maspin expression.

Autor: Futscher BW; Department of Pharmacology and Toxicology, Bone Marrow Transplant Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA. bfutscher@azcc.arizona.edu, Oshiro MM, Wozniak RJ, Holtan N, Hanigan CL, Duan H, Domann FE

Publikováno v: Nature genetics [Nat Genet] 2002 Jun; Vol. 31 (2), pp. 175-9. Date of Electronic Publication: 2002 May 20.