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The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs.

Autor: Tocheva AS; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom; Anna.Tocheva@nyumc.org sgadola@gmail.com.; Department of Medicine, New York University School of Medicine, New York, NY 10016., Mansour S; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom., Holt TG; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom., Jones S; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom., Chancellor A; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom., Sanderson JP; AdaptImmune Ltd., Abingdon OX14 4RY, United Kingdom., Eren E; Department of Clinical Immunology, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom., Elliott TJ; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom., Holt RI; Human Development and Health, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom; and., Gadola SD; Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton National Health Service Foundation Trust, Southampton SO17 1BJ, United Kingdom; Anna.Tocheva@nyumc.org sgadola@gmail.com.; Translational medicine, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Feb 15; Vol. 198 (4), pp. 1452-1459. Date of Electronic Publication: 2017 Jan 06.