Dioxygenase-catalysed mono-, di- and tri-oxygenation of dialkyl sulfides and thioacetals

Autor: Howard Dalton, Christopher C. R. Allen, André Alves-Areias, Brian T. McMurray, Alistair W. T. King, Derek R. Boyd, Narain D. Sharma, Holt Robert Antony, John F. Malone, Simon A. Haughey

Publikováno v: Boyd, D R, Sharma, N D, Haughey, S A, Malone, J F, King, A W T, McMurray, B T, Alves-Areias, A, Allen, C C R, Holt, R & Dalton, H 2001, ' Dioxygenase-catalysed mono-, di-and tri-oxygenation of dialkyl sulfides and thioacetals : Chemoenzymatic synthesis of enantiopure cis-diol sulfoxides ', Journal of the Chemical Society. Perkin Transactions 1, vol. 24, pp. 3288-3296 . https://doi.org/10.1039/b108620k

Toluene dioxygenase (TDO)-catalysed monooxygenation of methylsulfanylmethyl phenyl sulfide 1 and methylsulfanylmethyl 2-pyridyl sulfide 4, using whole cells of Pseudomonas putida UV4, occurred exclusively at the alkyl aryl sulfur centre to yield the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d49b6865e7aa007b8b7a0f5b1262df8
https://doi.org/10.1039/b108620k

Yeast Catalysed Reduction of β-Keto Esters (1): Factors Affecting Whole-Cell Catalytic Activity and Stereoselectivity

Autor: John Crosby, Keith O. Hallinan, David H. G. Crout, Anthony S. Carter, Howard Dalton, Jonathan R. Hunt, J. Colin Murrell, Holt Robert Antony

Publikováno v: Biocatalysis and Biotransformation. 12:159-178

Six yeasts were studied for their ability to reduce ethyl 4-chloroacetoacetate (ethyl 4-chloro-3-oxobutanoate) stereoselectively. Five species reduced the substrate to ethyl (S)-4-chloro-3-hydroxybutanoate of high (92–99%) optical purity. With gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e856d23853eb74ba1cebb1c458a8da8d
https://doi.org/10.3109/10242429508998160

Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria

Autor: Christopher C. R. Allen, Steven D. Shepherd, Howard Dalton, Derek R. Boyd, Alistair W. T. King, Heather R. Luckarift, Holt Robert Antony, Narain D. Sharma

Publikováno v: Boyd, D R, Sharma, N D, King, A W T, Shepherd, S D, Allen, C C R, Holt, R A, Luckarift, H R & Dalton, H 2004, ' Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria ', Organic and Biomolecular Chemistry, vol. 2, no. 4, pp. 554-561 . https://doi.org/10.1039/b313714g

Direct and indirect evidence, of unexpected stereoselective reductase-catalysed deoxygenations of sulfoxides, was found. The deoxygenations proceeded simultaneously, with the expected dioxygenase-catalysed asymmetric sulfoxidation of sulfides, during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab9eeb03483a1fd6e603def4e8d3ffc
https://cris.vtt.fi/en/publications/8d8565bf-affc-49c5-a7a0-4d662cf968c9

Biotransformations using clostridia: stereospecific reductions of a β-keto ester

Autor: Helmut Simon, Holt Robert Antony, David H. G. Crout, Markus Christen, J. Gareth Morris

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :491-493

The reduction of methyle 4-(4-chlorophenylthio)-3-oxobutanoate 1 by clostridia has been studied. Clostridium pasteurianum ATCC 6013, C. tyrobutyricum DSM 1460 and C. kluyveri NCIB 10680 gave the D-(3S) reduction product 2, whereas C. kluyveri DSM 555

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08e49864ebc4aaf6b97696c2fee799ea
https://doi.org/10.1039/p19920000491