Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Holt N. Murray"'
Publikováno v:
JTCVS Techniques. 13:131-134
Autor:
Neena Chandrasekaran, Syed Mahmood, Hernando Gomez, Holt N. Murray, Joseph A. Carcillo, Renee Anderko, John A. Kellum
Publikováno v:
Critical Care Medicine. 46:730-730
Publikováno v:
Annals of Emergency Medicine. 43:585-591
Study objective The early detection of intracranial hypertension can lead to timely medical and neurosurgical intervention, preventing brain herniation and death. In this investigation, we hypothesize that an increase in intracranial pressure can be
Publikováno v:
Resuscitation. 55:329-336
Previous studies suggest glucose, insulin and potassium (GIK) infusion during ischemia reduces infarct size and improves post-ischemic myocardial function in acute myocardial infarction and following surgical revascularization of the heart. The poten
Publikováno v:
Critical Care Medicine. 30:2542-2547
OBJECTIVE In this study, we test the hypothesis that a period of low flow perfusion before full reperfusion improves ventricular function and bioenergetics. DESIGN Prospective, randomized, controlled animal study. SETTING Research laboratory. SUBJECT
Autor:
Anne J. Baird, Paul G. Sleph, Holt N. Murray, W L Rogers, F L Wang, Gary J. Grover, David W. Green
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 274:H90-H97
Mitochondrial F1F0adenosinetriphosphatase (ATPase) is responsible for the majority of ATP synthesis during normoxic conditions, but under ischemic conditions it accounts for significant ATP hydrolysis. A previous study showed that preconditioning in
Autor:
Petr Paucek, Gary J. Grover, Vladimir Yarov-Yarovoy, Raymond B. Darbenzio, Holt N. Murray, Nicholas J. Lodge, Keith D. Garlid, Mark A. Smith, Albert J. D'Alonzo
Publikováno v:
Circulation Research. 81:1072-1082
Abstract Previous studies showed a poor correlation between sarcolemmal K + currents and cardioprotection for ATP-sensitive K + channel (K ATP ) openers. Diazoxide is a weak cardiac sarcolemmal K ATP opener, but it is a potent opener of mitochondrial
Autor:
Karnail S. Atwal, Gary J. Grover, Holt N. Murray, Mary W. Wilde, S Dzwonczyk, Carol A. Sargent, Jeffrey G. Tuttle
Publikováno v:
Cardiovascular Research. 31:270-277
Objectives: A myocardial calcium-independent PLA2 has been described that is activated during myocardial ischemia and this enzyme may modulate ATP-sensitive potassium channels (KATP). The aim of this study was to determine the effect of an inhibitor
Autor:
Anne J. Baird, S Dzwonczyk, Paul G. Sleph, Edward O. Weselcouch, Gary J. Grover, Holt N. Murray
Publikováno v:
Cardiovascular Research. 29:126-132
Objective: The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. Methods
Publikováno v:
Critical Care
Is a health care provider's most proximal obligation to individuals or society as a whole? Our International panel of critical care providers grapple over the issue of whether patient–physician confidentiality exists as an open ended ideal it shoul