Combinatorial, additive and dose-dependent drug-microbiome associations

Autor: Forslund, SK, Chakaroun, R, Zimmermann-Kogadeeva, M, Markó, L, Aron-Wisnewsky, J, Nielsen, T, Moitinho-Silva, L, Schmidt, TSB, Falony, G, Vieira-Silva, S, Adriouch, S, Alves, RJ, Assmann, K, Bastard, J-P, Birkner, T, Caesar, R, Chilloux, J, Coelho, LP, Fezeu, L, Galleron, N, Helft, G, Isnard, R, Ji, B, Kuhn, M, Le Chatelier, E, Myridakis, A, Olsson, L, Pons, N, Prifti, E, Quinquis, B, Roume, H, Salem, J-E, Sokolovska, N, Tremaroli, V, Valles-Colomer, M, Lewinter, C, Søndertoft, NB, Pedersen, HK, Hansen, TH, Amouyal, C, Andersson Galijatovic, EA, Andreelli, F, Barthelemy, O, Batisse, J-P, Belda, E, Berland, M, Bittar, R, Blottière, H, Bosquet, F, Boubrit, R, Bourron, O, Camus, M, Cassuto, D, Ciangura, C, Collet, J-P, Dao, M-C, Djebbar, M, Doré, A, Engelbrechtsen, L, Fellahi, S, Fromentin, S, Galan, P, Gauguier, D, Giral, P, Hartemann, A, Hartmann, B, Holst, JJ, Hornbak, M, Hoyles, L, Hulot, J-S, Jaqueminet, S, Jørgensen, NR, Julienne, H, Justesen, J, Kammer, J, Krarup, N, Kerneis, M, Khemis, J, Kozlowski, R, Lejard, V, Levenez, F, Lucas-Martini, L, Massey, R, Martinez-Gili, L, Maziers, N, Medina-Stamminger, J, Montalescot, G, Moute, S, Neves, AL, Olanipekun, M, Le Pavin, LP, Poitou, C, Pousset, F, Pouzoulet, L, Rodriguez-Martinez, A, Rouault, C, Silvain, J, Svendstrup, M, Swartz, T, Vanduyvenboden, T, Vatier, C, Walther, S, Gøtze, JP, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Hercberg, S, Oppert, J-M, Letunic, I, Nielsen, J, Bäckhed, F, Ehrlich, SD, Dumas, M-E, Raes, J, Pedersen, O, Clément, K, Stumvoll, M, Bork, P, The MetaCardis Consortium (Hoyles, L.)

Publikováno v: Nature
Nature, 2021, 600 (7889), pp.500-505. ⟨10.1038/s41586-021-04177-9⟩

During the transition from a healthy state to cardiometabolic disease, patients become heavily medicated, which leads to an increasingly aberrant gut microbiome and serum metabolome, and complicates biomarker discovery1-5. Here, through integrated mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d63d45a4e7d6e8c270f49c7d2bf0ce1
http://edoc.mdc-berlin.de/21160/1/21160oa.pdf

Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

Autor: Matikainen N, Björnson E, Söderlund S, Borén C, Eliasson B, Pietiläinen KH, Bogl LH, Hakkarainen A, Lundbom N, RIVELLESE, ANGELA ALBAROSA, RICCARDI, GABRIELE, Després JP, Alméras N, Holst JJ, Deacon CF, Borén J, Taskinen MR

CONTEXT: Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified. OBJECTIVE: To ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::55e966db7541a7a41af8589101aceb6d
http://hdl.handle.net/11588/638246

Postprandial GLP-1 response in inversely associated with liver fat

Autor: IDekker M, Rijkelijkhuizen JM, Alssema M, Doesburg T, Holst JJ, Mari A, Williams-Herman DE, Rhodes T, Gastaldelli A, Nijpels G, Girman CJ

Publikováno v: Diabetes (N.Y.N.Y.) (2009).
info:cnr-pdr/source/autori:IDekker M, Rijkelijkhuizen JM, Alssema M, Doesburg T, Holst JJ, Mari A, Williams-Herman DE, Rhodes T, Gastaldelli A, Nijpels G and Girman CJ/titolo:Postprandial GLP-1 response in inversely associated with liver fat/doi:/rivista:Diabetes (N.Y.N.Y.)/anno:2009/pagina_da:/pagina_a:/intervallo_pagine:/volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::c971b5559af0ef035a14cb4e8c9189ea
http://www.cnr.it/prodotto/i/112580

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients

Autor: Balas B, Baig MR, Watson C, Dunning BE, Ligueros-Saylan M, Wang Y, He YL, Darland C, Holst JJ, Deacon CF, Cusi K, Mari A, Foley JE, DeFronzo RA

Publikováno v: 92 (2007): 1249–1255.
info:cnr-pdr/source/autori:Balas B, Baig MR, Watson C, Dunning BE, Ligueros-Saylan M, Wang Y, He YL, Darland C, Holst JJ, Deacon CF, Cusi K, Mari A, Foley JE and DeFronzo RA,/titolo:The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients/doi:/rivista:/anno:2007/pagina_da:1249/pagina_a:1255/intervallo_pagine:1249–1255/volume:92

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::da13a4458cde861294506875840374dc
http://www.cnr.it/prodotto/i/30370

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