Parallel Minisci Reaction of gem -Difluorocycloalkyl Building Blocks.

Autor: Holovach S; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02066, Ukraine., Poroshyn I; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Melnykov KP; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Liashuk OS; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Pariiska OO; L. V. Pisarzhevskii Institute of Physical Chemistry of National Academy of Sciences of Ukraine, Nauky Avenue 31, Kyïv 03028, Ukraine., Kolotilov SV; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; L. V. Pisarzhevskii Institute of Physical Chemistry of National Academy of Sciences of Ukraine, Nauky Avenue 31, Kyïv 03028, Ukraine., Rozhenko AB; Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02066, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Volochnyuk DM; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02066, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Grygorenko OO; Enamine Ltd., Winston Churchill Street 78, Kyïv 02094, Ukraine.; Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02066, Ukraine.

Publikováno v: ACS organic & inorganic Au [ACS Org Inorg Au] 2024 May 15; Vol. 4 (4), pp. 424-431. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).

Fluorinated Cycloalkyl Building Blocks for Drug Discovery.

Autor: Grygorenko OO; Enamine Ltd., Chervonotkatska Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyїv, Volodymyrska Street 60, Kyїv, 01601, Ukraine., Melnykov KP; Enamine Ltd., Chervonotkatska Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyїv, Volodymyrska Street 60, Kyїv, 01601, Ukraine., Holovach S; Enamine Ltd., Chervonotkatska Street 78, Kyїv, 02094, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyїv, 02660, Ukraine., Demchuk O; Enamine Ltd., Chervonotkatska Street 78, Kyїv, 02094, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyїv, 02660, Ukraine.

Publikováno v: ChemMedChem [ChemMedChem] 2022 Nov 04; Vol. 17 (21), pp. e202200365. Date of Electronic Publication: 2022 Oct 05.

Effect of gem-Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes.

Autor: Holovach S; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv, 02660, Ukraine., Melnykov KP; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Skreminskiy A; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine., Herasymchuk M; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Tavlui O; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Aloshyn D; Bienta / Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine., Borysko P; Bienta / Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine., Rozhenko AB; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv, 02660, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Ryabukhin SV; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Volochnyuk DM; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv, 02660, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine., Grygorenko OO; Enamine Ltd., Chervonotkatska Street 78, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01601, Ukraine.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Apr 01; Vol. 28 (19), pp. e202200331. Date of Electronic Publication: 2022 Mar 04.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

分子骨架编辑在药物合成中的应用与展望.

Autor: 贺静远¹, 王泽铠¹, 戚显玮¹, 陈开元², 卞江¹ bj@pku.edu.cn

Publikováno v: University Chemistry. 2023, Vol. 38 Issue 10, p313-323. 11p.