BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.

Autor: Judd AS; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Bawa B; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Buck WR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Tao ZF; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Li Y; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mitten MJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Bruncko M; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Catron N; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Doherty G; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Durbin KR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Enright B; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Frey R; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haasch D; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haman S; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haight AR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Henriques TA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Holms J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Izeradjene K; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Judge RA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Jenkins GJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Kunzer A; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Leverson JD; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Martin RL; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mitra D; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mittelstadt S; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Nelson L; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Nimmer P; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Palma J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Peterson R; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Phillips DC; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Ralston SL; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Rosenberg SH; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Shen X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Song X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Vaidya KS; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Wang X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Wang J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Xiao Y; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Zhang H; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Zhang X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Blomme EA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Boghaert ER; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Kalvass JC; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Phillips A; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Souers AJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA.

Publikováno v: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eado7120. Date of Electronic Publication: 2024 Oct 04.

β-Catenin/Smad3 Interaction Regulates Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition in the Lens.

Autor: Taiyab A; Department of Pathology and Molecular Medicine, McMaster Health Sciences Center, Hamilton, ON L8N 3Z5, Canada. taiyab@mcmaster.ca., Holms J; Department of Pathology and Molecular Medicine, McMaster Health Sciences Center, Hamilton, ON L8N 3Z5, Canada. holmsjp@mcmaster.ca., West-Mays JA; Department of Pathology and Molecular Medicine, McMaster Health Sciences Center, Hamilton, ON L8N 3Z5, Canada. westmayj@mcmaster.ca.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2019 Apr 27; Vol. 20 (9). Date of Electronic Publication: 2019 Apr 27.

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects.

Autor: Chandler CH; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Chari S; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Kowalski A; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Choi L; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Tack D; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., DeNieu M; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Pitchers W; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Sonnenschein A; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Marvin L; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Hummel K; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Marier C; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Victory A; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Porter C; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Mammel A; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America., Holms J; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Sivaratnam G; Department of Biology, McMaster University, Hamilton, Ontario, Canada., Dworkin I; Department of Integrative Biology, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI, United States of America.; Department of Biology, McMaster University, Hamilton, Ontario, Canada.

Publikováno v: PLoS genetics [PLoS Genet] 2017 Nov 22; Vol. 13 (11), pp. e1007075. Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2017).

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