Using native mass spectrometry to study the role of homo-oligomeric proteins in gene regulation by using TRAP as a model protein system

Autor: Holmquist, Melody L.

Allostery is central in many biological regulatory systems, effectively turning genes on and off. Tryptophan (Trp) biosynthesis in Bacillus is one instance, tightly regulated by a feedback loop of allosteric interactions between a protein and a ligan

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=osu1595571760595304

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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers.

Autor: Jones SP; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Cook KH; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Holmquist ML; National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, New York, USA., Almekinder LJ; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Delaney AM; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Charles R; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Labbe N; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Perdue J; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Jackson N; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Pichichero ME; Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York, USA., Kaur R; Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York, USA., Michel LV; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA., Gleghorn ML; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA.

Publikováno v: Proteins [Proteins] 2023 Feb; Vol. 91 (2), pp. 161-170. Date of Electronic Publication: 2022 Sep 16.