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pro vyhledávání: '"Holmans P"'
Autor:
Jessica H. Hall, Samuel J. R. A. Chawner, IMAGINE-ID consortium, Jeanne Wolstencroft, David Skuse, Jeremy Hall, Peter Holmans, Michael J. Owen, Marianne B. M. van den Bree
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract A range of rare mutations involving micro-deletion or -duplication of genetic material (copy number variants (CNVs)) have been associated with high neurodevelopmental and psychiatric risk (ND-CNVs). Irritability is frequently observed in chi
Externí odkaz:
https://doaj.org/article/81154eda50754e09b297917153b839e0
Autor:
Claire E. Tume, Sophie L. Chick, Peter A. Holmans, Elliott Rees, Michael C. O’Donovan, Darren Cameron, Nicholas J. Bray
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100345- (2024)
Background: The prefrontal cortex (PFC) has been strongly implicated in the pathophysiology of schizophrenia. Here, we combined high-resolution single-nuclei RNA sequencing data from the human PFC with large-scale genomic data for schizophrenia to id
Externí odkaz:
https://doaj.org/article/98a6613cea174bff997f3b04330cabb4
Background/aims: While randomized controlled trials are the gold standard for measuring causal effects, robust conclusions about causal relationships can be obtained using data from observational studies if proper statistical techniques are used to a
Externí odkaz:
http://arxiv.org/abs/2112.05035
Observational studies are often used to understand relationships between exposures and outcomes. They do not, however, allow conclusions about causal relationships to be drawn unless statistical techniques are used to account for the imbalance of con
Externí odkaz:
http://arxiv.org/abs/2107.09009
Autor:
Markoulidakis, Andreas, Taiyari, Khadijeh, Holmans, Peter, Pallmann, Philip, Busse, Monica, Godley, Mark D., Griffin, Beth Ann
Randomized controlled trials are the gold standard for measuring causal effects. However, they are often not always feasible, and causal treatment effects must be estimated from observational data. Observational studies do not allow robust conclusion
Externí odkaz:
http://arxiv.org/abs/2010.09563
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Akademický článek
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Akademický článek
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Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 490 (2008)
Abstract Background DNA microarrays, which determine the expression levels of tens of thousands of genes from a sample, are an important research tool. However, the volume of data they produce can be an obstacle to interpretation of the results. Clus
Externí odkaz:
https://doaj.org/article/3cb30db47f16460984c1b7341f84ded7
Publikováno v:
BMC Psychiatry, Vol 7, Iss 1, p 26 (2007)
Abstract Background Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced condition although indicators of environmental risk including maternal smoking during pregnancy, low birth weight and low social class have also been foun
Externí odkaz:
https://doaj.org/article/5bc6907a69d440e8bf0f8b787dd3a4ef