Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Autor: Leung, E, Patel, J, Hollywood, JA, Zafar, A, Tomek, P, Barker, D, Pilkington, LI, van Rensburg, M, Langley, RJ, Helsby, NA, Squire, CJ, Baguley, BC, Denny, WA, Reynisson, J, Leung, IKH

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a05f9f33ee3b7576028ed9d6116e9bad
https://eprints.keele.ac.uk/9819/1/TDP1.pdf

Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis.

Autor: Hollywood JA; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Kallingappa PK; Vernon Jansen Unit, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Cheung PY; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Martis RM; Department of Physiology, The University of Auckland, Auckland, New Zealand., Sreebhavan S; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., 'Atiola RD; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Chatterjee A; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Buckels EJ; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Matthews BG; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Lewis PM; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Davidson AJ; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2022 Aug 01; Vol. 323 (2), pp. F156-F170. Date of Electronic Publication: 2022 Jun 13.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.

Autor: Leung E; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. e.leung@auckland.ac.nz.; Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. e.leung@auckland.ac.nz.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. e.leung@auckland.ac.nz., Patel J; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Hollywood JA; Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Zafar A; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Tomek P; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Barker D; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand.; The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, PO Box 600, Wellington, 6140, New Zealand., Pilkington LI; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., van Rensburg M; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Langley RJ; Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Helsby NA; Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Squire CJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand.; School of Biological Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Baguley BC; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand., Reynisson J; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. j.reynisson@keele.ac.uk.; School of Pharmacy and Bioengineering, Keele University, Staffordshire, ST5 5BG, UK. j.reynisson@keele.ac.uk., Leung IKH; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. ivanhoe.leung@unimelb.edu.au.; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. ivanhoe.leung@unimelb.edu.au.; School of Chemistry, The University of Melbourne, Parkville, VIC, 3010, Australia. ivanhoe.leung@unimelb.edu.au.; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia. ivanhoe.leung@unimelb.edu.au.

Publikováno v: Oncology and therapy [Oncol Ther] 2021 Dec; Vol. 9 (2), pp. 541-556. Date of Electronic Publication: 2021 Jun 23.

Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis.

Autor: Hollywood JA; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand a.davidson@auckland.ac.nz t.holm@auckland.ac.nz j.hollywood@auckland.ac.nz., Przepiorski A; Department of Developmental Biology, University of Pittsburgh, Pennsylvania., D'Souza RF; Discipline of Nutrition, The University of Auckland, Auckland, New Zealand., Sreebhavan S; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Wolvetang EJ; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia., Harrison PT; Department of Physiology, Biosciences Institute, University College Cork, Cork, Ireland., Davidson AJ; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Holm TM; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand a.davidson@auckland.ac.nz t.holm@auckland.ac.nz j.hollywood@auckland.ac.nz.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2020 May; Vol. 31 (5), pp. 962-982. Date of Electronic Publication: 2020 Mar 20.

Cas9/gRNA targeted excision of cystic fibrosis-causing deep-intronic splicing mutations restores normal splicing of CFTR mRNA.

Autor: Sanz DJ; Department of Physiology, BioSciences Institute, University College Cork, Cork, Ireland., Hollywood JA; Department of Physiology, BioSciences Institute, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., Scallan MF; School of Microbiology, University College Cork, Cork, Ireland., Harrison PT; Department of Physiology, BioSciences Institute, University College Cork, Cork, Ireland.

Publikováno v: PloS one [PLoS One] 2017 Sep 01; Vol. 12 (9), pp. e0184009. Date of Electronic Publication: 2017 Sep 01 (Print Publication: 2017).