Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Holly Y. Chen"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of clinically and genetically heterogenous disorders that lead to progressive vision impairment or blindness. Although each disorder
Externí odkaz:
https://doaj.org/article/5d5d3a6aadd54565a9c677c615607c14
Autor:
Florian Regent, Zachary Batz, Ryan A. Kelley, Linn Gieser, Anand Swaroop, Holly Y. Chen, Tiansen Li
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) recapitulate key features of retinogenesis and provide a promising platform to study retinal development and disease in a human context. Although multiple protocols are current
Externí odkaz:
https://doaj.org/article/19a7abd63dc04d12b484009ffea433a9
Autor:
Matthew J. Brooks, Holly Y. Chen, Ryan A. Kelley, Anupam K. Mondal, Kunio Nagashima, Natalia De Val, Tiansen Li, Vijender Chaitankar, Anand Swaroop
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 891-905 (2019)
Summary: Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that tr
Externí odkaz:
https://doaj.org/article/55d75f04bc144eb088aab1172e9f26fa
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100018- (2020)
Summary: Mouse pluripotent stem cells can be efficiently differentiated into retinal organoids with polarized, laminated neural retina harboring all retinal cell types by the Hypoxia-Induced Generation of Photoreceptor in Retinal Organoids (HIPRO) pr
Externí odkaz:
https://doaj.org/article/41dfe311da7845528f3a1b8836cd333d
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100033- (2020)
Summary: Human pluripotent stem cells (PSCs) can be differentiated into retinal organoids with proper neural layer organization, yet the protocols are technically challenging and time consuming. We have modified a widely used differentiation protocol
Externí odkaz:
https://doaj.org/article/b9c5825780fa4cf4aada6f671109df36
Autor:
Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop
Publikováno v:
eLife, Vol 12 (2023)
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To
Externí odkaz:
https://doaj.org/article/d7b516710de643d58647394ef7678b1a
Autor:
Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2140ff55ea36b5c6f2347a8d42639c39
https://doi.org/10.7554/elife.83205.sa2
https://doi.org/10.7554/elife.83205.sa2
Autor:
Holly Y. Chen, Manju Swaroop, Samantha Papal, Anupam K. Mondal, Gregory J. Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G. Jacobson, Wei Zheng, Anand Swaroop
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multiorgan pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd3da62732e2111ab85d29896c9d453
https://doi.org/10.1101/2022.09.14.22279917
https://doi.org/10.1101/2022.09.14.22279917
Publikováno v:
Seminars in cell & developmental biology
The primary cilium is a ubiquitous microtubule-based organelle that senses external environment and modulates diverse signaling pathways in different cell types and tissues. The cilium originates from the mother centriole through a complex set of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91473b3e179915e767ff9289cea9960a
http://europepmc.org/articles/PMC7855621
http://europepmc.org/articles/PMC7855621
Autor:
Tiansen Li, Natalia de Val, Kunio Nagashima, Ryan A. Kelley, Holly Y. Chen, Matthew Brooks, Anand Swaroop, Vijender Chaitankar, Anupam Kumar Mondal
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 891-905 (2019)
Stem Cell Reports
Stem Cell Reports
Summary Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119f6127bec36f5ed77466687aa66065
http://www.sciencedirect.com/science/article/pii/S2213671119303388
http://www.sciencedirect.com/science/article/pii/S2213671119303388