Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Holly Van Remmen"'
Autor:
Shylesh Bhaskaran, Katarzyna M. Piekarz, Jacob Brown, Brian Yang, Sarah R. Ocañas, Jonathan D. Wren, Constantin Georgescu, Christopher Bottoms, Ashley Murphy, Jessica Thomason, Debra Saunders, Nataliya Smith, Rheal Towner, Holly Van Remmen
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was tested at two do
Externí odkaz:
https://doaj.org/article/0e640ce65630411f9790072628df78b8
Autor:
Madeline R. Hines, Piedad C. Gomez-Contreras, Suryamin Liman, Alexandria M. Wilson, Kevin J. Lu, Jaycie A. O'Neill, Jacob S. Fisher, Douglas C. Fredericks, Brett A. Wagner, Garry R. Buettner, Holly Van Remmen, Mitchell C. Coleman
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103306- (2024)
In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used tert-butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stre
Externí odkaz:
https://doaj.org/article/817362ea08d7463e9414d0fd6087f442
Autor:
Madison Milan, Jacob Brown, Colleen L. O'Reilly, Matthew P. Bubak, Sharon Negri, Priya Balasubramanian, Arjune S. Dhanekula, Gavin Pharaoh, Zeke Reyff, Cade Ballard, Helen Shi, Andriy Yabluchanskiy, Michael C. Rudolph, Zoltan Ungvari, David J. Marcinek, Benjamin F. Miller, Holly Van Remmen, Stefano Tarantini
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103189- (2024)
Age-related endothelial dysfunction is a pivotal factor in the development of cardiovascular diseases, stemming, at least in part, from mitochondrial dysfunction and a consequential increase in oxidative stress. These alterations are central to the d
Externí odkaz:
https://doaj.org/article/466071c57c3547ceab1a2acc4685fbd1
Autor:
Agnieszka Czyżowska, Jacob Brown, Hongyang Xu, Kavitha Sataranatarajan, Michael Kinter, Victoria J. Tyrell, Valerie B. O'Donnell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102761- (2023)
Our previous studies support a key role for mitochondrial lipid hydroperoxides as important contributors to denervation-related muscle atrophy, including muscle atrophy associated with aging. Phospholipid hydroperoxide glutathione peroxidase 4 (GPX4)
Externí odkaz:
https://doaj.org/article/5ff81d932c6e4952806e59208fb00ab3
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102550- (2023)
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://doaj.org/article/81eb975c107342e8860817ab0704bc01
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1582-1596 (2021)
Abstract Background Oxidative stress and damage are associated with a number of ageing phenotypes, including age‐related loss of muscle mass and reduced contractile function (sarcopenia). Our group and others have reported loss of neuromuscular jun
Externí odkaz:
https://doaj.org/article/9bac5f8dec0d46829cc8a059124a8aef
Autor:
Kamil A. Kobak, Marcus M. Lawrence, Gavin Pharaoh, Agnieszka K. Borowik, Frederick F. Peelor III, Patrick D. Shipman, Timothy M. Griffin, Holly Van Remmen, Benjamin F. Miller
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1764-1775 (2021)
Abstract Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of protein turnover because of the advantages of long‐term labelli
Externí odkaz:
https://doaj.org/article/aa72846333cd446ba42eb4b4e82c5fc9
Autor:
Hongyang Xu, Holly Van Remmen
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA functi
Externí odkaz:
https://doaj.org/article/fc66fbb1f57c48fe992a1dcc2f39124d
Autor:
Jacob L. Brown, Fredrick F. Peelor, III, Constantin Georgescu, Jonathan D. Wren, Michael Kinter, Victoria J. Tyrrell, Valerie B. O'Donnell, Benjamin F. Miller, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102518- (2022)
Loss of innervation is a key driver of age associated muscle atrophy and weakness (sarcopenia). Our laboratory has previously shown that denervation induced atrophy is associated with the generation of mitochondrial hydroperoxides and lipid mediators
Externí odkaz:
https://doaj.org/article/3239a27805754d5683dbbbba59aaf6a0
Autor:
Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov, X. F. Steven Zheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The superoxide dismutase SOD1 is highly expressed in lung cancer but its role has not fully investigated yet. In this study, the authors demonstrate that SOD1 regulates ribosome biogenesis driving KRAS-driven lung tumorigenesis.
Externí odkaz:
https://doaj.org/article/10e3267362bc477794a94e24c0dbd94f