Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Holly V. Adcock"'
Autor:
Martin L. Read, Caitlin Thornton, Hannah Nieto, Liam R. Cox, Vicki Smith, Rashida Khan, Holly V. Adcock, Luke J. Alderwick, Christopher McCabe, Katie Brookes, Alice Fletcher, Mohammed Alshahrani, Jamie R.M. Webster, Kristien Boelaert
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d1af3f23453cb12056726bf775b93d
https://doi.org/10.1530/endoabs.70.oc5.4
https://doi.org/10.1530/endoabs.70.oc5.4
Autor:
Christopher J McCabe, Vicki E Smith, Kristien Boelaert, Luke J Alderwick, Liam Cox, Jamie R M Webster, Holly V Adcock, Hannah R Nieto, Rashida Khan, Mohammed Alshahrani, Caitlin E M Thornton, Alice Fletcher, Katie Brookes, Martin L Read
Publikováno v:
Journal of the Endocrine Society
New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58b7be9a18971802b391919d837f844
https://doi.org/10.1210/jendso/bvaa046.2135
https://doi.org/10.1210/jendso/bvaa046.2135
Publikováno v:
European Journal of Organic Chemistry. 2018:4696-4704
The biological significance of sp3-rich synthetic scaffolds with natural product-like features yet distinct global frameworks is being increasingly recognised in medicinal chemistry and biochemistry. Taking inspiration from the vast array of bioactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::414c2e58f1dc86c2d7d8d13c0b8d7982
https://doi.org/10.1002/ejoc.201800962
https://doi.org/10.1002/ejoc.201800962
Autor:
Christopher J. Moody, William Lewis, Christopher A. Pearce, Elena G. Merisor, Ian Strutt, Daniel Hamza, Steven M. Wales, Holly V. Adcock
Publikováno v:
Chemistry - A European Journal. 24:8233-8239
A series of highly substituted tetrahydrofurans (THFs), decorated with modifiable 2-aryl, 3-carboxy and 4-amino substituents, has been prepared for biological evaluation within the European Lead Factory. Diastereoselective reductive amination of pre-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fcfb4aa87f4011268eba577beecd44
https://doi.org/10.1002/chem.201801046
https://doi.org/10.1002/chem.201801046
Publikováno v:
ChemInform. 47
The reaction N-allyl ynamides in the presence of Au(picolinate)Cl2 gives polycyclic heterocycles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cad9eba8cf61d22ce15edce91171af5
https://doi.org/10.1002/chin.201616131
https://doi.org/10.1002/chin.201616131
Autor:
Paul W. Davies, Holly V. Adcock
Publikováno v:
Synthesis. 44:3401-3420
The rapidly expanding field of gold and platinum π-acid catalysis has led to the discovery of diverse transformations that are initiated with nucleophilic attack onto a metal-activated alkyne. This review brings together those reactions which employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5727580da20bd697ad21808cfb94c842
https://doi.org/10.1055/s-0032-1316788
https://doi.org/10.1055/s-0032-1316788
Publikováno v:
Angewandte Chemie (International Ed. in English)
Gold carbene reactivity patterns were accessed by ynamide insertion into a C(sp3)—H bond. A substantial increase in molecular complexity occurred through the cascade polycyclization of N‐allyl ynamides to form fused nitrogen‐heterocycle scaffol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6196d6a9accc8531660758e57da80bc
https://pubmed.ncbi.nlm.nih.gov/26515958
https://pubmed.ncbi.nlm.nih.gov/26515958
Publikováno v:
ChemInform. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f573b77409d5d1e01ea073f92ce824
https://doi.org/10.1002/chin.201449098
https://doi.org/10.1002/chin.201449098
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Unique α-hemiaminal ether gold carbene intermediates were accessed by a gold-catalysed 1,1-carboalkoxylation strategy and evolved through a highly selective 1,2-N-migration. This skeletal rearrangement gave functionalised indenes, and isotopic label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3edd475347764afcee2b0e5ec0b0b004
https://pubmed.ncbi.nlm.nih.gov/24828030
https://pubmed.ncbi.nlm.nih.gov/24828030
Autor:
Holly V. Adcock, Paul W. Davies
Publikováno v:
ChemInform. 44
The rapidly expanding field of gold and platinum π-acid catalysis has led to the discovery of diverse transformations that are initiated with nucleophilic attack onto a metal-activated alkyne. This review brings together those reactions which employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbd547ef5a32c5c9c16094491489607
https://doi.org/10.1002/chin.201307216
https://doi.org/10.1002/chin.201307216