Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Holly Strohmeyer"'
Autor:
Sutton Scott Channing, Daniel W. Widlicka, Christopher B. Morris, Holly Strohmeyer, Cheryl Myers Hayward, Sebastien Monfette, Lindsay D. Nicholson, Jean-Nicolas Desrosiers, Michael Paul Burns, Jeremy Steflik, Eric C. Hansen, Michele T. Buetti-Weekly, Paul Bowles, Rajesh Kumar, Lu Han, Ian Hotham, Kris N. Jones, Shengquan Duan
Publikováno v:
Organic Process Research & Development. 26:879-890
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc34dbcb23d301db40b9f2245611b52f
https://doi.org/10.1021/acs.oprd.1c00255
https://doi.org/10.1021/acs.oprd.1c00255
Autor:
Maria M. O’Sullivan, Eric M. Cordi, Jon Blunt, Gregory W. Sluggett, Ciaran Byrne, John A. Ragan, Brian G. Conway, Corey L. Stanchina, Sandra Mullane, Esmort Chisowa, Stuart Taylor, Janice E. Sieser, Denis Lynch, Leo Joseph Letendre, Marcella Whelan, Holly Strohmeyer, Robert A. Singer, Paul Bowles, Kyle R. Leeman
Publikováno v:
Organic Process Research & Development. 18:26-35
This is the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1). This contribution describes development of an Evans aldol reaction to control the tertiary alcohol stereocenter, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e980e41e3c1612b4046300761480666
https://doi.org/10.1021/op4002356
https://doi.org/10.1021/op4002356
Autor:
Stuart Taylor, Gregory W. Sluggett, Brian G. Conway, Leo Joseph Letendre, Robert A. Singer, Nicola Mawby, Kevin Meldrum, Jon Blunt, Zhihui Peng, Kyle R. Leeman, John A. Ragan, Holly Strohmeyer, Eric M. Cordi, Li-Jen Ping, Janice E. Sieser, Roberto Colon-Cruz, Brian C. Vanderplas
Publikováno v:
Organic Process Research & Development. 18:36-44
This paper describes an improved sequence for the conversion of an oxazolidinone (3) to a β-keto lactone (5). The primary drivers behind this change were the modest and variable yields observed in the intramolecular cyclization to generate the β-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249802ea1a0efa9c951d4e02f1bee3a6
https://doi.org/10.1021/op400236r
https://doi.org/10.1021/op400236r
Autor:
Gregory W. Sluggett, Holly Strohmeyer
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 62
The synthesis of filibuvir, a hepatitis C virus polymerase inhibitor candidate, involves use of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), a potentially genotoxic free radical reagent. A headspace gas chromatographic method utilizing selected-ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9560fa7e95b323f48a9dcd4a72aee432
https://pubmed.ncbi.nlm.nih.gov/22269174
https://pubmed.ncbi.nlm.nih.gov/22269174
Autor:
Carol A. Kingsmill, Darren L. Reid, Holly Strohmeyer, Majid Mahjour, Anita L. Freed, Vikram Sadineni
Publikováno v:
International journal of pharmaceutics. 357(1-2)
Finding formulations that prevent degradation of the active pharmaceutical ingredient is an essential part of drug development. One of the major mechanisms of degradation is oxidation. Oxidative degradation is complex, and can occur via different mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e29ed69f3a090f43d1f2a90e68e593
https://pubmed.ncbi.nlm.nih.gov/18400425
https://pubmed.ncbi.nlm.nih.gov/18400425