Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Holly S. Savage"'
Autor:
Holly S. Savage, Kelsey Letson, Susan Sheehan, Bernard Davenport, Daniel M Gatti, Valerie Wright, Rachel Lennon, Yuka Takemon, Ron Korstanje
Publikováno v:
J Am Soc Nephrol
Background Mutations in COL4A5 are responsible for 80% of cases of X-linked Alport Syndrome (XLAS). Although genes that cause AS are well characterized, people with AS who have similar genetic mutations present with a wide variation in the extent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24119513935f86d14489b5b8b8c84812
https://pubmed.ncbi.nlm.nih.gov/34045313
https://pubmed.ncbi.nlm.nih.gov/34045313
Autor:
Susan Sheehan, Holly S. Savage, Sean Eddy, Anna Reznichenko, Grant Backer, Yuka Takemon, Matthias Kretzler, Ron Korstanje
Publikováno v:
Physiological Genomics. 50:543-552
Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as a candidate gene associated with differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78064a9689295ea57e3ad121748b6481
https://doi.org/10.1152/physiolgenomics.00118.2017
https://doi.org/10.1152/physiolgenomics.00118.2017
Autor:
Bonnie L Lyons, Holly S. Savage, Kevin G Kane, Jennifer L Ryan, Stacey J. Sukoff Rizzo, Ron Korstanje
Publikováno v:
Endocrinology. 158:2707-2712
Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment affecting behavior and measurements. In the current study, we measured blood glucose and bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc9acd7e1200642cb2bf4143410a3cf
https://doi.org/10.1210/en.2017-00266
https://doi.org/10.1210/en.2017-00266
Autor:
Beverly Paigen, Annerose Berndt, Randy Von Smith, Tim Stearns, Adriana S. Leme, Holly S. Savage, Steven D. Shapiro, Laura K. Williams, Shirng-Wern Tsaih, Karen L. Svenson, Luanne L. Peters
Publikováno v:
Physiological Genomics. 43:1-11
Lung function detection in mice is currently most accurately measured by invasive techniques, which are costly, labor intensive, and terminal. This limits their use for large-scale or longitudinal studies. Noninvasive assays are often used instead, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341f6021b331271114fd893c2e0eb8bb
https://doi.org/10.1152/physiolgenomics.00108.2010
https://doi.org/10.1152/physiolgenomics.00108.2010
Autor:
Hermann Haller, Ron Korstanje, Patricia Schroder, Holly S. Savage, Mario Schiffer, Patricia Bolanos-Palmieri, Konstantin Deutsch, Ian Roberts, Nils Hanke, Jan Hinrich Bräsen, Susan Sheehan, Lynne Staggs
Publikováno v:
Journal of the American Society of Nephrology : JASN. 27(11)
Changes in metabolite levels of the kynurenine pathway have been observed in patients with CKD, suggesting involvement of this pathway in disease pathogenesis. Our recent genetic analysis in the mouse identified the kynurenine 3-mono-oxygenase (KMO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d040f3b7d868205d51194998f60efe5
https://pubmed.ncbi.nlm.nih.gov/27020856
https://pubmed.ncbi.nlm.nih.gov/27020856
Autor:
Magalie S. Leduc, Annerose Berndt, Holly S. Savage, Tim Stearns, Clinton L. Cario, Beverly Paigen, Kenneth Walsh
Publikováno v:
Molecular genetics and genomics : MGG. 287(11-12)
Chronic kidney disease is a common disease with increasing prevalence in the western population. One common reason for chronic kidney failure is diabetic nephropathy. Diabetic nephropathy and hyperglycemia are characteristics of the mouse inbred stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db8d132842cb25baf0baf622a758db2
https://pubmed.ncbi.nlm.nih.gov/23011808
https://pubmed.ncbi.nlm.nih.gov/23011808
Publikováno v:
Molecular Genetics and Genomics
Vitamin D receptor (VDR) polymorphisms are associated with an increased asthma incidence in human populations; however, observations in Vdr knockout mice are unclear. The aim of our study was to determine the influence of the genetic variation in Vdr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df40e80f472027b3ee9464da2b17fdd
https://pubmed.ncbi.nlm.nih.gov/21850575
https://pubmed.ncbi.nlm.nih.gov/21850575
Autor:
Phyllis A. Magnani, Nadav Ahituv, Holly S. Savage, Beverly Paigen, Rebecca S. Durgin, Oded Foreman, Luanne L. Peters, Karen L. Svenson
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 11, Pp 2452-2462 (2008)
In an effort to discover new mouse models of cardiovascular disease using N-ethyl-N-nitrosourea (ENU) mutagenesis followed by high-throughput phenotyping, we have identified a new mouse mutation, C699Y, in the LDL receptor (Ldlr), named wicked high c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed729fec70fa82f24a6703f6103334e0
https://pubmed.ncbi.nlm.nih.gov/18632552
https://pubmed.ncbi.nlm.nih.gov/18632552
Autor:
Rachael Hageman Blair, Seungbum Choi, Ron Korstanje, Matt Hibbs, Aleksandra Aljakna, Holly S. Savage, Tongjun Gu, Karen L. Svenson, Gary A. Churchill
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43139 (2012)
PLoS ONE
PLoS ONE
Despite considerable progress understanding genes that affect the HDL particle, its function, and cholesterol content, genes identified to date explain only a small percentage of the genetic variation. We used N-ethyl-N-nitrosourea mutagenesis in mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf96f879ca2ad069ef2087c26c3c8ab
https://doi.org/10.1371/journal.pone.0043139
https://doi.org/10.1371/journal.pone.0043139