Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Holly S. Goetzman"'
Autor:
Amanda M. Pugh, Nicholas J. Auteri, Holly S. Goetzman, Charles C. Caldwell, Vanessa Nomellini
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1741 (2017)
Critically ill patients that survive sepsis can develop a Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS), which often leads to extended recovery periods and multiple complications. Here, we utilized a cecal ligation and pu
Externí odkaz:
https://doaj.org/article/1c9c498281c047e589da7802b27003ce
Autor:
John G. Noel, Seth W. Ramser, Lori Pitstick, Holly S. Goetzman, Elizabeth L. Dale, Andrew Potter, Mike Adam, S. Steven Potter, Jason C. Gardner
Publikováno v:
The Journal of Immunology. 210:972-980
The anemia of critical illness (ACI) is a nearly universal pathophysiological consequence of burn injury and a primary reason burn patients require massive quantities of transfused blood. Inflammatory processes are expected to drive postburn ACI and
Autor:
Charles C. Caldwell, Christian B. Bergmann, Holly S. Goetzman, Bruce D. Hammock, Dorothy M. Supp, Falk Gogolla, Debin Wan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific reports, vol 11, iss 1
Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated to amelio
Autor:
Mackenzie C. Morris, Kathleen E. Singer, Michael D. Goodman, Amy T. Makley, Ryan Moran, Emily McGlone, Charles C. Caldwell, Devin John, Holly S. Goetzman, Rosalie Veile
Publikováno v:
Thromb Res
Introduction Traumatic brain injury (TBI) induces acute hypocoagulability, subacute hypercoagulability, and persistently elevated risk for thromboembolic events. Splenectomy is associated with increased mortality in patients with moderate or severe T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ab5736e20bb4f4710b8ec35656f376
https://europepmc.org/articles/PMC7484105/
https://europepmc.org/articles/PMC7484105/
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Hepatic ischemia-reperfusion (I/R) is a major complication of liver resection, trauma, and liver transplantation; however, liver repair after I/R in diseased liver has not been studied. The present study sought to determine the manner in which the fi
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
The CXC chemokine receptor 2 (CXCR2) is critical for neutrophil recruitment and hepatocellular viability but has not been studied in the context of cholestatic liver injury following bile duct ligation (BDL). The present study sought to elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba7e627886ca430b934f022a9821c8d
https://europepmc.org/articles/PMC6962495/
https://europepmc.org/articles/PMC6962495/
Autor:
Timothy A. Pritts, Mark D. Johnson, Amy T. Makley, Charles C. Caldwell, Holly S. Goetzman, Rosalie A Veile, Lou Ann Friend, Ryan M. Boudreau, Michael D. Goodman
Publikováno v:
Journal of Surgical Research. 215:47-54
Background Posttraumatic coagulopathy and inflammation can exacerbate secondary cerebral damage after traumatic brain injury (TBI). Tranexamic acid (TXA) has been shown clinically to reduce mortality in hemorrhaging and head-injured trauma patients a
Autor:
Young Kim, Michael D. Goodman, Rosalie Veile, Brent T. Xia, Vanessa Nomellini, Charles C. Caldwell, Nadine Beckmann, Erich Gulbins, Holly S. Goetzman, Leah K. Winer
During sepsis, the early innate response and inflammatory cytokine cascade are associated with activation of the coagulation cascade. Acute hypercoagulability can contribute to lethal sequela of vascular thrombosis, tissue ischemia, and organ failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91888452e30f2177ac3dd5b04153438
https://www.ncbi.nlm.nih.gov/pubmed/29608550
https://www.ncbi.nlm.nih.gov/pubmed/29608550
Autor:
Holly S. Goetzman, David A. Hildeman, Kevin R. Kasten, Jonathan R. Dattilo, Johannes Tschöp, Cindy M. Cave, Aaron P. Seitz, Lisa G. England, Charles C. Caldwell
Publikováno v:
Shock. 34:377-383
Survival during sepsis requires both swift control of infectious organisms and tight regulation of the associated inflammatory response. As the role of T cells in sepsis is somewhat controversial, we examined the impact of increasing antigen-dependen
Autor:
Holly S. Goetzman, Chad T. Robinson, Lisa G. England, Johannes Tschöp, Cindy M. Cave, Jonathan R. Dattilo, Samuel G. Adediran, Charles C. Caldwell, Derrick J. N. Dauplaise, Kevin R. Kasten
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299:R918-R925
Following burn injury, the host is susceptible to bacterial infections normally cleared by healthy patients. We hypothesized that during the systemic immune response that follows scald injury, the host's altered immune status increases infection susc