Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Holly Reeve"'
Autor:
Jack Rowbotham, Jake Nicholson, Miguel Ramirez, Kouji Urata, Peter Todd, Gogulan Karunanithy, Lars Lauterbach, Holly Reeve, Andrew Baldwin, Kylie Vincent
Biocatalysis offers many advantages for selective isotopic labelling of valuable small molecules, such as the deuterated amino acids utilised in protein NMR. Until recently, applications of biocatalytic deuteration systems have been restricted by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39bdf9526e28bf4fa8bbba80a25dfc0
https://doi.org/10.26434/chemrxiv-2022-82tz0
https://doi.org/10.26434/chemrxiv-2022-82tz0
Commercially available carbon-supported metal (metal/C) catalysts are investigated here for direct H2-driven NAD+ reduction. Selected metal/C catalysts are thenused for H2 oxidation with electrons transferred via the conductive carbon support materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067ca74f515fbc8b8c9b89c74580959d
https://doi.org/10.26434/chemrxiv.13365386
https://doi.org/10.26434/chemrxiv.13365386
Barriers to the ready adoption of biocatalysis into asymmetric synthesis for early stage medicinal chemistry are addressed, using ketone reduction by alcohol dehydrogenase as a model reaction. An efficient substrate screening approach is used to show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349b11e03ef5bcc2d7b7a41664756318
https://doi.org/10.26434/chemrxiv.13134767
https://doi.org/10.26434/chemrxiv.13134767
Translation of redox biocatalysis into a commercial H-Cube hydrogenation flow reactor was achieved using immobilized enzyme systems for biocatalytic hydrogenations. Carbon-supported enzymes for H2-driven NADH recycling and NADH-dependent C=O reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f00accadec2d8268ed753ddcf754a0
https://doi.org/10.26434/chemrxiv.12532301.v1
https://doi.org/10.26434/chemrxiv.12532301.v1
Chemicals labelled with the heavy hydrogen isotope deuterium (2H) have long been used in chemical and biochemical mechanistic studies, spectroscopy, and as analytical tracers. More recently, demonstration of selectively deuterated drug candidates tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90335f20f338ce255b85dde41f124e08
https://doi.org/10.26434/chemrxiv.7982864
https://doi.org/10.26434/chemrxiv.7982864