Výsledky vyhledávání - "Holly R. Brooker"

Phosphoregulation of tropomyosin is crucial for actin cable turnover and division site placement

Autor: Holly R. Brooker, Juan Ramon Hernandez-Fernaud, Daniel P. Mulvihill, Taishi Kanamaru, Darius Vasco Köster, Saravanan Palani, Anton Kamnev, Jonathan B. A. Millar, Alexandra M. E. Jones, Mohan K. Balasubramanian, Tomoyuki Hatano

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology

Palani et al. reveal a new mechanism by which the F-actin binding protein tropomyosin is regulated. They find that phosphorylation of tropomyosin reduces its affinity for F-actin, allowing the competing Adf1 to bind and sever actin filaments.
Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5d75ffc77449d7151e163bccea2aa6
http://europepmc.org/articles/PMC6829654

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Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions

Autor: Daniel P. Mulvihill, Michael A. Geeves, Holly R. Brooker

Publikováno v: Febs Letters

The dynamic nature of actin polymers is modulated to facilitate a diverse\ud range of cellular processes. These dynamic properties are modulated by\ud different isoforms of Tropomyosin, which are recruited to distinct subpopulations\ud of actin polym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1e74015b054d8b939c9f3bf9a64864
https://doi.org/10.1002/1873-3468.12346

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A novel live-cell imaging system reveals a reversible hydrostatic pressure impact on cell-cycle progression

Autor: Agnieszka Wieckowska, Nicholas J. Brooks, Irene A Gyamfi, Daniel P. Mulvihill, Michael A. Geeves, Holly R. Brooker

Publikováno v: Journal of Cell Science

Life is dependent upon the ability of a cell to rapidly respond to changes in the environment. Small perturbations in local environments change the ability of molecules to interact and, hence, communicate. Hydrostatic pressure provides a rapid non-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d3cff7c7b688451251d44494a2a03b
http://europepmc.org/articles/PMC6104828

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Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin- tropomyosin copolymer

Autor: Michael A. Geeves, Elisabeth Grimsey, Holly R. Brooker, Elliot G. Wilson, Chloe A. Johnson, Annette Dean, James Embling, Jodie E. Brazier, Alice C. Tomlinson, Daniel P. Mulvihill, Jennifer O'Brien, Brogan Ashley, Irene A Gyamfi

Publikováno v: Biochemical and Biophysical Research Communications

The actin cytoskeleton is modulated by regulatory actin-binding proteins which fine-tune the dynamic properties of the actin polymer to regulate function. One such actin-binding protein is tropomyosin (Tpm), a highly-conserved alpha-helical dimer whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ec212821be2742b45e974d6c1d028a

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An enhanced recombinant amino-terminal acetylation system and novel in vivo high-throughput screen for molecules affecting α-synuclein oligomerisation

Autor: Tara A, Eastwood, Karen, Baker, Holly R, Brooker, Stefanie, Frank, Daniel P, Mulvihill

Publikováno v: Febs Letters

Amino‐terminal acetylation is a ubiquitous protein modification affecting the majority of eukaryote proteins to regulate stability and function. We describe an optimised recombinant expression system for rapid production of amino terminal‐acetyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::395c070004438831b73b50a74c4d6f05
https://pubmed.ncbi.nlm.nih.gov/28214355

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