Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Holly Moots"'
Autor:
Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 326 (2024)
Amino acid restriction induces cellular stress and cells often respond via the induction of autophagy. Autophagy or ‘self-eating’ enables the recycling of proteins and provides the essential amino acids needed for cell survival. Of the naturally
Externí odkaz:
https://doaj.org/article/83076f736ef943178b3651a7c3bf56b4
Autor:
Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v:
Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Autor:
Holly Moots, Sara Cronk, Sharifa Dinara, Jenna Thomas, Houssine Ikhlef, Otto Phanstiel, Chelsea Massaro
Publikováno v:
Journal of Medicinal Chemistry. 63:2814-2832
Targeting polyamine metabolism is a proven anticancer strategy. Cancers often escape the polyamine biosynthesis inhibitors by increased polyamine import. Therefore, there is much interest in identifying polyamine transport inhibitors (PTIs) to be use
Autor:
Otto Phanstiel, Holly Moots
Publikováno v:
The FASEB Journal. 33