Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Holly McConville"'
Autor:
Claire White, Heather Difilippo, Megan Harvey, Laura S Motley, Holly McConville, Colleen Callahan
Publikováno v:
Clinical Journal of Oncology Nursing. 21
Autor:
Joan Gilmore, Saar Gill, Stephan A. Grupp, Lester Lledo, Simon F. Lacey, Alison W. Loren, Anne Chew, Noelle V. Frey, Holly McConville, Carl H. June, Anthony R. Mato, J. Joseph Melenhorst, Michael Kalos, Pamela A. Shaw, Stephen J. Schuster, James Capobianchi, Bruce L. Levine, Katherine T. Marcucci, David L. Porter, Wei-Ting Hwang
Publikováno v:
Journal of Clinical Oncology. 34:3009-3009
3009Background: Autologous T cells genetically modified to express a CD19-targeting CAR (CTL019) can mediate potent anti-tumor effects in CLL and other CD19+ malignancies. Since CTL019 are self-rep...
Autor:
Katherine T. Marcucci, Simon F. Lacey, Carl H. June, Alexey Bersenev, Yolanda D. Mahnke, Zoe Zheng, Joseph J Melenhorst, Mariusz A. Wasik, Sunita D. Nasta, Jakub Svoboda, Anthony R. Mato, Noelle V. Frey, Stephen J. Schuster, David L. Porter, Neel Manvar, Anne Chew, Holly McConville, Anne Lamontagne, Pamela A. Shaw, Jens Hasskar, Elise A. Chong, Bruce L. Levine, Alfred L. Garfall, Joan Shea, Daniel J. Landsburg, Matthew O'Rourke, Gaurav D. Shah
Publikováno v:
Cytotherapy. 17:S13
Autor:
Simon F. Lacey, Yolanda D. Mahnke, Anne Chew, Katherine T. Marcucci, Noelle V. Frey, Daniel J. Landsburg, Joanne Shea, Anthony R. Mato, Holly McConville, Sunita D. Nasta, Mariusz A. Wasik, Bruce L. Levine, Jakub Svoboda, Jens Hasskarl, David L. Porter, Alfred L. Garfall, Carl H. June, Zhaohui Zheng, Stephen J. Schuster, J. Joseph Melenhorst, Manuel Litchman, Elise A. Chong, Gaurav D. Shah
Publikováno v:
Blood. 124:3087-3087
BACKGROUND: Autologous T cells genetically modified to express a chimeric antigen receptor consisting of an external anti-CD19 single chain antibody domain with CD3ζ and 4-1BB signaling domains (CTL019 cells) can mediate potent anti-tumor effects in
Autor:
Simon F. Lacey, Manuel Litchman, James Capobianchi, Wei-Ting Hwang, David L. Porter, Stephan A. Grupp, Carl H. June, Katherine T. Marcucci, Lester Lledo, Noelle V. Frey, Bruce L. Levine, Yolanda D. Mahnke, Holly McConville, Patricia A. Wood, Alison W. Loren, Anne Chew, J. Joseph Melenhorst, Pamela A. Shaw, Zhaohui Zheng, Angela Shen, Michael Kalos, Joan Gilmore
Publikováno v:
Blood. 124:1982-1982
BACKGROUND: We have shown that infusion of autologous T cells genetically modified to express a chimeric antigen receptor (CAR) consisting of an external anti-CD19 domain, with the CD3z and 4-1BB signaling domains (CTL019 cells), can mediate potent a
Autor:
Simon F. Lacey, James Capobianchi, Lester Lledo, J. Joseph Melenhorst, Christina Jemison, Zhaohui Zheng, Anne Chew, Bruce L. Levine, Joan Gilmore, Holly McConville, Alison W. Loren, Carl H. June, David L. Porter
Publikováno v:
Leukemia Research. 38:S12
with a distinct clinical outcome, and may be predictive of refractoriness to most available drugs. For this subset of patients, a number of novel non-chemotherapeutic therapies have demonstrated an unprecedented efficacy with longer progression free
Autor:
David L. Porter, Lester Lledo, Zhaohui Zheng, Noelle V. Frey, Holly McConville, James Capobianchi, Bruce L. Levine, Anne Chew, Carl H. June, Stephan A. Grupp, Alison W. Loren, Christina Jemison, Michael Kalos, Joan Gilmore
Publikováno v:
Blood. 122:4162-4162
Background Chimeric antigen receptors (CARs) combine the antigen recognition domain of an antibody with intracellular signaling domains into a single chimeric protein. CD19 is an ideal target for CARs since expression is restricted to normal and mali
Autor:
David L. Porter, Michael Kalos, Noelle V. Frey, Stephan A Grupp, Alison W. Loren, Christina Jemision, Joan Gilmore, Holly McConville, James Capobianchi, Lester Lledo, Anne Chew, Angela Shen, Patricia A. Wood, Manuel Litchman, Zhaohui Zheng, Bruce L. Levine, Carl H. June
Publikováno v:
Blood. 122:873-873
Background Patients (pts) with relapsed, and/or refractory (R/R) CLL have a poor prognosis with few effective treatment options. We have shown that infusion of autologous T cells genetically modified to express a chimeric antigen receptor (CAR) consi
Autor:
Anne Chew, Alison W. Loren, Noelle V. Frey, Bruce L. Levine, Angela Shen, David L. Porter, Patricia A. Wood, Holly McConville, Charlene So, Carl H. June, Joan Gilmore, Michael Kalos, Michele Sharr
Publikováno v:
Journal of Clinical Oncology. 31:TPS7132-TPS7132
TPS7132 Background: The poor prognosis and lack of effective treatment options for patients with r/r CLL highlight the need for novel therapies in this setting. CD19 is a promising anticancer target because it is broadly expressed on normal and malig
Autor:
Erica Suppa, Irina Kulikovskaya, Alan D. Bennett, Holly McConville, Elizabeth Veloso, Tatiana Mikheeva, Minnal Gupta, Zoe Zheng, B.K. Jacobsen, Andrew B. Gerry, Dan T. Vogl, Julio Cotte, Nick Pumphrey, Jeffrey Finklestein, Andrea L. Brennan, Joanna E. Brewer, A. Badros, Carl H. June, Alexey Bersenev, D.P. Smethurst, G.K. Binder-Scholl, T. Tripic, Sandra Westphal, Aaron P. Rapoport, Brendan M. Weiss, Edward A. Stadtmauer, Saul Yanovich, Naseem Kerr, Bruce L. Levine, Kelly-Marie Betts, E. Cribioli, Michael Kalos, L. Ribiero, Sunita Philip, H.K. Tayton-Martin, Gorgun Akpek
Publikováno v:
Cytotherapy. 15:S13
Advanced atherosclerotic lesions are characterized by lipid accumulation, chronic inflammation, and defective efferocytosis; an ideal therapy should address all aspects of this multi-factorial disease. Ixmyelocel-T, an expanded autologous multicellul