Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Holly Maulhardt"'
1
Phase 1/2 Trial Results of a Large Surface Area Microparticle Docetaxel for the Treatment of High-Risk Nonmuscle-Invasive Bladder Cancer
Autor: Max, Kates, Ahmed M, Mansour, Donald L, Lamm, Neal, Shore, Holly, Maulhardt, Alison, Wendt, James, Verco, Alyson, Marin, Karan, Dewnani, Shelagh, Verco, Gere S, diZerega
Publikováno v: Journal of Urology. 208:821-829
We investigated the safety, preliminary efficacy, and immune effects of large surface area microparticle docetaxel (LSAM-DTX) administered by direct injection after transurethral resection of bladder tumor (TURBT), and by intravesical instillation in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398de2ee6995fe169b44e2a1e77bfbe1
https://doi.org/10.1097/ju.0000000000002778
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2
Local administration of large surface area microparticle docetaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects: preclinical and clinical studies
Autor: Holly, Maulhardt, Shelagh, Verco, Michael, Baltezor, Alyson, Marin, Gere, diZerega
Publikováno v: Drug Delivery and Translational Research. 13:503-519
This report describes local administration of large surface area microparticle docetaxel (LSAM-DTX: ~ 3.5- to 7.5-µm-sized particles with high relative surface area) in preclinical oncology models and in a clinical trial in urothelial carcinoma. Red
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1612c01a9530364e6fdb17ddd889ad3
https://doi.org/10.1007/s13346-022-01226-2
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3
Local administration of submicron particle paclitaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects without local or systemic toxicity: preclinical and clinical studies
Autor: Alison Wendt, Sam Campbell, Gere S. diZerega, Marc Iacobucci, Michael Baltezor, Holly Maulhardt, Paul Dorman, Shelagh Verco, Alyson Marin, Emily Williams, James Verco
Publikováno v: Drug Delivery and Translational Research
This report describes local administration of submicron particle paclitaxel (SPP) (NanoPac®: ~ 800-nm-sized particles with high relative surface area with each particle containing ~ 2 billion molecules of paclitaxel) in preclinical models and clinic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1c3dd27f0fa98d945d6a630ab405cf
https://doi.org/10.1007/s13346-020-00868-4
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4
Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood
Autor: Holly Maulhardt, Alyson Marin, Gere S. diZerega
Publikováno v: Investigational New Drugs
SummaryAdministration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb12909aa44c89b04533c7650ffb76
https://doi.org/10.1007/s10637-020-00922-5
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5
LBA02-02 INITIAL RESULTS FROM A PHASE 1/2 TRIAL OF LARGE SURFACE AREA MICROPARTICLE DOCETAXEL FOR HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER
Autor: Neal D. Shore, Ahmed M. Mansour, Gere S. diZerega, Max Kates, Rose Marie Cavanna-Mast, Donald L. Lamm, Holly Maulhardt
Publikováno v: Journal of Urology. 206
INTRODUCTION AND OBJECTIVE:A Phase 1/2 clinical trial (NCT03636256) investigated the safety, preliminary efficacy, and immune effect of large surface area microparticle docetaxel (LSAM-DTX) given v...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7daaa646171b014eca0059af596f1b6
https://doi.org/10.1097/ju.0000000000002149.02
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6
Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions
Autor: Gere S. diZerega, Holly Maulhardt, Alyson Marin, Holly Hesseltine
Publikováno v: Medical Oncology (Northwood, London, England)
We describe here characterization of the response of local and metastatic disease and immunomodulation following intratumoral (IT) injection of submicron particle docetaxel (SPD) administered alone or in combination with systemic antibody anti-mCTLA-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b21681f4ea5535a5b1f51bf509dc8be
https://doi.org/10.1007/s12032-021-01555-1
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7
Local Injection of Submicron Particle Docetaxel is Associated with Tumor Eradication, Reduced Systemic Toxicity and an Immunologic Response in Uro-Oncologic Xenografts
Autor: David I. Quinn, Leanne Drummond, Michael V Frost, Ashley Tornio, Lauren Hylle, Sara Dafoe, Ashish M. Kamat, Holly Maulhardt, Gere S. diZerega
Publikováno v: Cancers, Vol 11, Iss 4, p 577 (2019)
Cancers
Volume 11
Issue 4
Intratumoral (IT) administration of submicron particle docetaxel (NanoDoce®
NanOlogy LLC, Fort Worth, TX, USA) and its efficacy against genitourinary-oncologic xenografts in rats and mice, xenograft-site docetaxel concentrations and immune-ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bb1efac79882c1a8e57ba90abce051
https://www.mdpi.com/2072-6694/11/4/577
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8
Development of a guinea pig cutaneous radiation injury model using low penetrating X-rays
Autor: Gere S. diZerega, Christopher J. Meeks, C.K. Hill, Holly Maulhardt, William Johnston, Melissa Donald, Theresa Espinoza, Kathleen E. Rodgers, Lila Kim, Alick Tan
Publikováno v: International Journal of Radiation Biology. 92:434-443
A guinea pig skin model was developed to determine the dose-dependent response to soft X-ray radiation into the dermis.X-ray exposure (50 kVp) was defined to a 4.0 × 4.0 cm area on the lateral surface of a guinea pig using lead shielding. Guinea pig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c216c2ecc620b433e7cef841267aac6
https://doi.org/10.1080/09553002.2016.1186302
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10
A phase I study of intraperitoneal nanoparticulate paclitaxel (Nanotax®) in patients with peritoneal malignancies
Autor: Maurie Markman, Holly J. Smith, Gary Johnson, Gere S. diZerega, D.S. McMeekin, Scott Weir, Michael Baltezor, Katherine F. Roby, Jo Wick, Christine B. Mackay, Holly Maulhardt, Kathleen M. Moore, Gregory A. Reed, Stephen K. Williamson, Thomas K. Schulz, Jahna C. Espinosa, Charles J. Decedue
Publikováno v: Cancer Chemotherapy and Pharmacology. 75:1075-1087
This multicenter, open-label, dose-escalating, phase I study evaluated the safety, tolerability, pharmacokinetics and preliminary tumor response of a nanoparticulate formulation of paclitaxel (Nanotax®) administered intraperitoneally for multiple tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7fd8abcc0658488d2a9e97da2730e1
https://doi.org/10.1007/s00280-015-2737-4
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