Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Holly M. Robb"'
Autor:
Yonghao Cao, Bohdan P. Harvey, Liang Jin, Susan Westmoreland, Jing Wang, Munish Puri, Yingli Yang, Holly M. Robb, Sultan Tanriverdi, Chenqi Hu, Xue Wang, Xiaofeng Xin, Yingchun Liu, Michael P. Macoritto, Kathleen M. Smith, Yu Tian, Kevin White, Timothy R.D.J. Radstake, Zehra Kaymakcalan
Publikováno v:
JID Innovations, Vol 4, Iss 1, Pp 100250- (2024)
Adalimumab but neither etanercept nor certolizumab-pegol has been reported to induce a wound-healing profile in vitro by regulating macrophage differentiation and matrix metalloproteinase expression, which may underlie the differences in efficacy bet
Externí odkaz:
https://doaj.org/article/655145936f1542ad926ac42c32f1ff28
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
James J. Lee, Nina Ly, Rejani B. Kunjamma, Holly M. Robb, Eric G. Mohler, Janani Sridar, Qi Hao, José Zavala-Solorio, Chunlian Zhang, Ganesh Kolumam, Nick van Bruggen, Caitlin F. Connelly, Carmela Sidrauski
eIF2B is a decameric guanine nucleotide exchange factor (GEF) that is essential for protein synthesis and a key effector of the integrated stress response (ISR). Hypomorphic mutations in any of the eIF2B subunits are associated with Vanishing White M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a2d80061127e97b50c933f8fc1faa9d
https://doi.org/10.1101/2023.05.06.539602
https://doi.org/10.1101/2023.05.06.539602
Autor:
Nicole V Haste, Diana Donnelly-Roberts, Swathi Krishnan, Lauren LeBon, Jennifer M. Frost, Fiona E. McAllister, Andrea T. Ireland, Yao Liang Wong, Carmela Sidrauski, Stephan Riedmaier, Michael J. Dart, Kathy L. Kohlhaas, Lei Shi, Nimrod D. Rubinstein, Ana M. Basso, Janani Prakash, Kathleen A. Martin, Andrew M. Swensen, Arthur L. Nikkel, Jonathon J. O’Brien, Margaret Ann Roy, Holly M. Robb
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9990114b53b75c88cb58914a496683c
https://doi.org/10.7554/elife.42940
https://doi.org/10.7554/elife.42940
Autor:
Diana L. Donnelly-Roberts, Ana M. Basso, Arthur L. Nikkel, Andrea T. Ireland, Jennifer M. Frost, Lauren LeBon, Carmela Sidrauski, Stephan Riedmaier, Nimrod D. Rubinstein, Holly M. Robb, Kathleen A. Martin, Nicole V Haste, Fiona E. McAllister, Swathi Krishnan, Lei Shi, Margaret Ann Roy, Andrew M. Swensen, Janani Prakash, Jonathon J. O’Brien, Kathy L. Kohlhaas, Yao Liang Wong, Michael J. Dart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebd2110389786065142053652d6bb1f
https://doi.org/10.7554/elife.42940.036
https://doi.org/10.7554/elife.42940.036
Autor:
Ana M. Basso, Nimrod D. Rubinstein, Arthur L. Nikkel, Fiona E. McAllister, Jennifer M. Frost, Michael J. Dart, Janani Prakash, Diana Donnelly-Roberts, Kathleen A. Martin, Kathy L. Kohlhaas, Andrew M. Swensen, Lauren LeBon, Lei Shi, Jonathon J. O’Brien, Yao Liang Wong, Stephan Riedmaier, Swathi Krishnan, Nicole V Haste, Carmela Sidrauski, Holly M. Robb
The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bd23e32b80b51dd87fa6b42310ee3
Autor:
Karen T. Kaye, Arthur L. Nikkel, Eric G. Mohler, Jordan W. Brown, Tammy L. Dellovade, Chang Z. Zhu, Holly M. Robb, Victoria A. Roderwald
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa7f145250bc591ba7efba26ec6819b
https://doi.org/10.1016/j.jalz.2018.06.136
https://doi.org/10.1016/j.jalz.2018.06.136
Publikováno v:
Biochemical Pharmacology. 97:482-487
Schizophrenia is a chronic disease that has been hypothesized to be linked to neurodevelopmental abnormalities. Schizophrenia patients exhibit impairments in basic sensory processing including sensory gating deficits in P50 and mismatch negativity (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c112e5721b1b8bc1fa1fafb25bd0c24
https://doi.org/10.1016/j.bcp.2015.05.011
https://doi.org/10.1016/j.bcp.2015.05.011
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:736-745
Nicotinic acetylcholine receptor (nAChR) agonists improve sensory gating deficits in animal models and schizophrenic patients. The aim of this study was to determine whether the novel and selective α7 nAChR full agonist 5-(6-[(3R)-1-azabicyclo[2.2.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e0f6e05db6cb6d6c3618001093525
https://doi.org/10.1124/jpet.112.197970
https://doi.org/10.1124/jpet.112.197970
Autor:
Kathy Sarris, Clark A. Briggs, Gregory A. Gfesser, William H. Bunnelle, Sujatha M. Gopalakrishnan, Michael P. Curtis, Caroline Wetterstrand, Ramin Faghih, Richard J. Radek, John Malysz, Holly M. Robb, Jens Halvard Grønlien, Hilde Ween, Kennan C. Marsh, Rachid El-Kouhen, Murali Gopalakrishnan
Publikováno v:
Journal of Medicinal Chemistry. 52:3377-3384
The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of alpha7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), a novel type II PAM with good potency and selectivity. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e322c761752b465f16f2e130987ba
https://doi.org/10.1021/jm9003818
https://doi.org/10.1021/jm9003818