Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Holly M. Micolochick Steuer"'
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β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
Autor: Haiying Bao, Angela M. Lam, Shalini Bansal, Byoung-Kwon Chun, Michael J. Sofia, Holly M. Micolochick Steuer, Jinfa Du, Ying Jiang, Donghui Bao, Eisuke Murakami, Bruce S. Ross, Christine Espiritu, Michael J. Otto, Phillip A. Furman, Hai-Ren Zhang, P. Ganapati Reddy, Congrong Niu
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:5924-5929
The 3',5'-cyclic phosphate prodrug 9-[β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methylribofuranosyl]-2-amino-6-ethoxypurine, PSI-352938 1, has demonstrated promising anti-HCV efficacy in vitro and in human clinical trials. A structure-activity relationship
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f3942cad5d386e93ff9eb0cf5dc9ab
https://doi.org/10.1016/j.bmcl.2012.07.066
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6
Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
Autor: Holly M. Micolochick Steuer, Veronique Zennou, Christine Espiritu, Angela M. Lam, Shalini Bansal, Phillip A. Furman, Michael J. Otto
Publikováno v: Journal of Virology. 85:12334-12342
PSI-352938, a cyclic phosphate nucleotide, and PSI-353661, a phosphoramidate nucleotide, are prodrugs of β- d -2′-deoxy-2′-α-fluoro-2′-β- C -methylguanosine-5′-monophosphate. Both compounds are metabolized to the same active 5′-triphosph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6ab7e314243b8857d8b87ce700e852
https://doi.org/10.1128/jvi.05639-11
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7
2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
Autor: Holly M. Micolochick Steuer, Donghui Bao, Wonsuk Chang, Bruce S. Ross, Angela M. Lam, Shalini Bansal, Dhanapalan Nagarathnam, Michael J. Otto, P. Ganapati Reddy, Meg Keilman, Byoung-Kwon Chun, Congrong Niu, Hai-Ren Zhang, Rachakonda Suguna, Christine Espiritu, Phillip A. Furman, Jinfa Du, Michael J. Sofia
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:7376-7380
A series of novel 2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0894d7978cc2668811feded8aada3bad
https://doi.org/10.1016/j.bmcl.2010.10.035
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8
Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
Autor: Jinfa Du, Angela M. Lam, Shalini Bansal, Rachakonda Suguna, Congrong Niu, Meg Keilman, Michael J. Otto, Donghui Bao, Bruce S. Ross, Peiyuan Wang, Dhanapalan Nagarathnam, Wonsuk Chang, Holly M. Micolochick Steuer, Michael J. Sofia, Hai-Ren Zhang, Phillip A. Furman, P. Ganapati Reddy, Christine Espiritu
Publikováno v: Journal of Medicinal Chemistry. 53:7202-7218
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable target for the development of HCV therapies. β-d-2'-Deoxy-2'-α-fluor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70b0f48ff595e61d3a04db4332b1530
https://doi.org/10.1021/jm100863x
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