Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Holly M. Legault"'
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Autor:
Andrew Filer, Philipp Antczak, Greg N Parsonage, Holly M Legault, Margot O'Toole, Mark J Pearson, Andrew M Thomas, Dagmar Scheel-Toellner, Karim Raza, Christopher D Buckley, Francesco Falciani
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120917 (2015)
Synovial fibroblasts in persistent inflammatory arthritis have been suggested to have parallels with cancer growth and wound healing, both of which involve a stereotypical serum response programme. We tested the hypothesis that a serum response progr
Externí odkaz:
https://doaj.org/article/e27e205633494cda815af25738c13856
Autor:
Unnur S Bjornsdottir, Stephen T Holgate, Padmalatha S Reddy, Andrew A Hill, Charlotte M McKee, Cristina I Csimma, Amy A Weaver, Holly M Legault, Clayton G Small, Renee C Ramsey, Debra K Ellis, Conor M Burke, Philip J Thompson, Peter H Howarth, Andrew J Wardlaw, Phillip G Bardin, David I Bernstein, Louis B Irving, Geoffrey L Chupp, George W Bensch, Gregory W Bensch, Jon E Stahlman, Monroe Karetzky, James W Baker, Rachel L Miller, Brad H Goodman, Donald G Raible, Samuel J Goldman, Douglas K Miller, John L Ryan, Andrew J Dorner, Frederick W Immermann, Margot O'Toole
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21902 (2011)
Asthma exacerbations remain a major unmet clinical need. The difficulty in obtaining airway tissue and bronchoalveolar lavage samples during exacerbations has greatly hampered study of naturally occurring exacerbations. This study was conducted to de
Externí odkaz:
https://doaj.org/article/f4ed057e1067408a9023f1d201f1a2b4
Autor:
Dania Rabah, Ti Wang, Jeffery Vessels, Kevin Guckian, Chris Roberts, Andrea Bertolotti-Ciarlet, Norm Alliare, Agnes Gardet, Holly M. Legault, Ramon G. Bonegio, Ian R. Rifkin
Publikováno v:
Poster Presentations.
Background IRAK4 is an important signaling mediator of the innate immune system. IRAK4 initiates MyD88-dependent signaling from most TLRs and from IL-1Rs, resulting in downstream production of pro-inflammatory cytokines1. Objectives Inhibition of IRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbca7ad35dae288f2965000b98162f2
https://doi.org/10.1136/annrheumdis-2019-eular.3385
https://doi.org/10.1136/annrheumdis-2019-eular.3385
Autor:
Dania Rabah, Sarah Ryan, Robert Dunstan, Julia M. Czerkowicz, Taylor L. Reynolds, Kai Fu, Normand Allaire, Jeffrey L. Browning, Matvey E. Lukashev, Agnes Gardet, Joanne L. Viney, Wei C. Chou, Ann Ranger, Hannah M. Kerns, Jeffrey Bajko, Holly M. Legault, Diana B. Velez, Robert Lafyatis
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
PLoS ONE
PLoS ONE
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ffcf6e7f9b0c091105433f5dc7b58
http://europepmc.org/articles/PMC5070861?pdf=render
http://europepmc.org/articles/PMC5070861?pdf=render
Autor:
Philipp Antczak, Karim Raza, Andrew Filer, Greg Parsonage, Andrew M. C. Thomas, Dagmar Scheel-Toellner, Mark J. Pearson, Holly M. Legault, Christopher D. Buckley, Margot O'Toole, Francesco Falciani
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120917 (2015)
PLoS ONE, Vol 10, Iss 3, p e0120917 (2015)
Synovial fibroblasts in persistent inflammatory arthritis have been suggested to have parallels with cancer growth and wound healing, both of which involve a stereotypical serum response programme. We tested the hypothesis that a serum response progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e79579a4b83181fe5ebb451d1785ab6
https://pubmed.ncbi.nlm.nih.gov/25807374
https://pubmed.ncbi.nlm.nih.gov/25807374
Autor:
Andrew J. Dorner, Mark J. Collins, Samuel J. Goldman, Joseph P. Sypek, Holly M. Legault, Margot O'Toole, Stuart Murray, Wei Liu, Elizabeth Goad, Padmalatha S. Reddy
Publikováno v:
Arthritis Research & Therapy
Introduction Treatment with sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be efficacious in the MRL/lpr and NZB × NZW F1 mouse models of lupus nephritis, indicating a critical role for the mTOR pathway in both models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b12167f45cdeb93a1ca6d61058bfde
https://pubmed.ncbi.nlm.nih.gov/18980674
https://pubmed.ncbi.nlm.nih.gov/18980674
Autor:
Andrew A. Hill, Derek B. Janszen, Andrew J. Dorner, William M. Mounts, Debra K. Ellis, Margot O'Toole, Immermann Frederick, Krystyna Zuberek, Ronald S. Black, Holly M. Legault, Padmalatha S. Reddy, Donna K. Slonim, Maryann Z. Whitley
Publikováno v:
Archives of Neurology. 62:1531
Background A phase 2a, double-blind, placebo-controlled, multicenter study was conducted to evaluate safety, tolerability, and pilot efficacy of immunization with β-amyloid (1-42) in patients with Alzheimer disease. Six immunizations were planned bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b1173e613180202eb7e55afb38a751
https://doi.org/10.1001/archneur.62.10.1531
https://doi.org/10.1001/archneur.62.10.1531