Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Holly M Poling"'
Autor:
Akaljot Singh, Holly M Poling, Nambirajan Sundaram, Nicole Brown, James M Wells, Michael A Helmrath
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237885 (2020)
Our group has developed two transplantation models for the engraftment of Human Intestinal Organoids (HIOs): the renal subcapsular space (RSS) and the mesentery each with specific benefits for study. While engraftment at both sites generates laminate
Externí odkaz:
https://doaj.org/article/4df5319f91e4406ea55d08281fbc7442
Autor:
Manju Sharma, Maulee Sheth, Holly M. Poling, Damaris Kuhnell, Scott M. Langevin, Leyla Esfandiari
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Nano-scale extracellular vesicles are lipid-bilayer delimited particles that are naturally secreted by all cells and have emerged as valuable biomarkers for a wide range of diseases. Efficient isolation of small extracellular vesicles while
Externí odkaz:
https://doaj.org/article/b783d98f56b34dadad099e28bdb3ec8d
Autor:
Suman Pradhan, Sayali S. Karve, Alison A. Weiss, Jennifer Hawkins, Holly M. Poling, Michael A. Helmrath, James M. Wells, Heather A. McCauley
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 171-190 (2020)
Background & Aims: Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome. The murine inte
Externí odkaz:
https://doaj.org/article/6bbfdf62ec0b4631968dc0990ad90901
Autor:
Amy L. Pitstick, Holly M. Poling, Nambirajan Sundaram, Phillip L. Lewis, Daniel O. Kechele, J. Guillermo Sanchez, Melissa A. Scott, Taylor R. Broda, Michael A. Helmrath, James M. Wells, Christopher N. Mayhew
Publikováno v:
Stem Cell Reports. 17:1889-1902
A major technical limitation hindering the widespread adoption of human pluripotent stem cell (hPSC)-derived gastrointestinal (GI) organoid technologies is the need for de novo hPSC differentiation and dependence on spontaneous morphogenesis to produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe21fc03458475cc0b5f390bea1be83
https://doi.org/10.1016/j.stemcr.2022.06.011
https://doi.org/10.1016/j.stemcr.2022.06.011
Autor:
Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M. Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao
Publikováno v:
Hepatology Communications. 6:2702-2714
Biliary atresia (BA) is a neonatal inflammatory cholangiopathy that requires surgical intervention by Kasai portoenterostomy to restore biliary drainage. Even with successful portoenterostomy, most patients diagnosed with BA progress to end-stage liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e915858491befe41517eb1108210dd
https://doi.org/10.1002/hep4.2024
https://doi.org/10.1002/hep4.2024
Autor:
Carine Bouffi, Kathryn A. Wikenheiser-Brokamp, Praneet Chaturvedi, Nambirajan Sundaram, Gillian R. Goddard, Mark Wunderlich, Nicole E. Brown, Janet F. Staab, Rachel Latanich, Nicholas C. Zachos, Emily M. Holloway, Maxime M. Mahe, Holly M. Poling, Simon Vales, Garrett W. Fisher, Jason R. Spence, James C. Mulloy, Aaron M. Zorn, James M. Wells, Michael A. Helmrath
Publikováno v:
Nature Biotechnology.
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable model for investigating human intestinal organogenesis and physiology, but they lack the immune components required to fully recapitulate the complexity of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce9faf21e848f4514f04985168e1376
https://doi.org/10.1038/s41587-022-01558-x
https://doi.org/10.1038/s41587-022-01558-x
Autor:
Greg Tiao, Reena Mourya, Todd M. Jenkins, Bryan Donnelly, Phylicia Dupree, Holly M. Poling, Inna N. Lobeck, Ruchi Bansal, Ana Ortiz-Perez, Sujit K. Mohanty, Jorge A. Bezerra, Monica M. McNeal, Haley Temple, Sarah Mowery
Publikováno v:
Hepatology, 74(2), 864-878. Wiley
Background and Aims: Biliary atresia (BA) is a devastating cholangiopathy of infancy. Upon diagnosis, surgical reconstruction by Kasai hepatoportoenterostomy (HPE) restores biliary drainage in a subset of patients, but most patients develop fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a2d604f45c97e3be8376619b38572
http://www.scopus.com/inward/record.url?scp=85111487532&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85111487532&partnerID=8YFLogxK
Autor:
Maksym Krutko, Andrew Bryan, Maulee Sheth, Yara Izhiman, Holly M. Poling, Greg Harris, Leyla Esfandiari
Publikováno v:
Biophysical Journal. 122:431a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2da5d09a8512d7f3b8ac8f1ca704b56
https://doi.org/10.1016/j.bpj.2022.11.2334
https://doi.org/10.1016/j.bpj.2022.11.2334
Autor:
Daniel O Kechele, Alexandra K. Eicher, Lauren E. Haines, James M. Wells, Mansa Krishnamurthy, Michael A. Helmrath, J. G. Sanchez, Aaron M. Zorn, Keishi Kishimoto, Nambirajan Sundaram, Lu Han, Holly M. Poling, H. M. Berns
SUMMARYThe development of human organoid model systems has provided new avenues for patient-specific clinical care and disease modeling. However, all organoid systems are missing important cell types that, in the embryo, get incorporated into organ t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1685308fd52b9635e411417a411ee25
https://doi.org/10.1101/2021.07.15.452523
https://doi.org/10.1101/2021.07.15.452523
Autor:
Akaljot Singh, Holly M. Poling, Nambirajan Sundaram, James Wells, Amy E. O'Connell, Olga Kovbasnjuk, Michael Helmrath
Publikováno v:
Gastroenterology. 162:S-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514fdc9fa37030a1bfab8a45608e7b58
https://doi.org/10.1016/s0016-5085(22)60029-5
https://doi.org/10.1016/s0016-5085(22)60029-5